The complex connections between test properties and relevant outcomes: widening the perspective

Clinica Chimica Acta; International Journal of Clinical Chemistry
D L Witte

Abstract

The formulation of analytical goals for the clinical laboratory should be based upon a wide perspective embracing multiple viewpoints. Mathematical consideration of analytical error is necessary but insufficient to address societal forces demanding increased effectiveness while also reducing costs. Appropriate goals also require the study of cognitive science, health policy research, and the measurement of subjective preferences and of predictive probability. Overall goals must focus on health outcomes that emphasize prevention or postponement of morbidity and the need for acute care. Care process variables that influence health outcomes must be identified. Process improvement through reduction in process variation can then improve health outcomes. Important process variables will be identified in the cognitive process as well as in the pre- and post-analytical phases of laboratory care. The impact of test characteristics upon the laboratory's contribution to health goals are exemplified by monitoring of oral anticoagulant, thyroxine, aminoglycoside and intensive insulin therapy plus identification of clinically occult diseases such as hypothyroidism and hemochromatosis.

References

Apr 1, 1991·Scandinavian Journal of Clinical and Laboratory Investigation·P WiggersM Hørder
Jun 1, 1989·Annals of Internal Medicine·J P Kassirer
Jan 1, 1986·Journal of Chronic Diseases·G D FriedmanB H Fireman
Jan 1, 1982·Annals of Internal Medicine·S A Finkler
May 15, 1980·The New England Journal of Medicine·S G Pauker, J P Kassirer
Jul 17, 1980·The New England Journal of Medicine·J F Fries
Dec 4, 1980·The New England Journal of Medicine
Jan 30, 1981·Science·A Tversky, D Kahneman
May 11, 1995·The New England Journal of Medicine·G Viberti
Jan 1, 1995·Medical Care·W M TierneyC J McDonald
Apr 1, 1995·Annals of Internal Medicine·J TsevatL Goldman
Jul 1, 1994·Arteriosclerosis and Thrombosis : a Journal of Vascular Biology·M LozanoJ J Sixma
Jun 3, 1993·The New England Journal of Medicine·C Q Edwards, J P Kushner
Apr 1, 1994·Medical Care·J P KahanR H Brook
Dec 30, 1993·The New England Journal of Medicine·G A Maguire
Sep 30, 1993·The New England Journal of Medicine·UNKNOWN Diabetes Control and Complications Trial Research GroupC Siebert
Oct 21, 1993·The New England Journal of Medicine·C E Phelps
Oct 21, 1993·The New England Journal of Medicine·J P Kassirer
Sep 27, 1974·Science·A Tversky, D Kahneman

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Citations

Jul 11, 2000·Archives of Pathology & Laboratory Medicine·T M St JohnT L Hearn

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