The complex contributions of genetics and nutrition to immunity in Drosophila melanogaster

PLoS Genetics
Robert L UncklessBrian P Lazzaro

Abstract

Both malnutrition and undernutrition can lead to compromised immune defense in a diversity of animals, and "nutritional immunology" has been suggested as a means of understanding immunity and determining strategies for fighting infection. The genetic basis for the effects of diet on immunity, however, has been largely unknown. In the present study, we have conducted genome-wide association mapping in Drosophila melanogaster to identify the genetic basis for individual variation in resistance, and for variation in immunological sensitivity to diet (genotype-by-environment interaction, or GxE). D. melanogaster were reared for several generations on either high-glucose or low-glucose diets and then infected with Providencia rettgeri, a natural bacterial pathogen of D. melanogaster. Systemic pathogen load was measured at the peak of infection intensity, and several indicators of nutritional status were taken from uninfected flies reared on each diet. We find that dietary glucose level significantly alters the quality of immune defense, with elevated dietary glucose resulting in higher pathogen loads. The quality of immune defense is genetically variable within the sampled population, and we find genetic variation for immunological ...Continue Reading

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Citations

Jan 19, 2016·Current Biology : CB·Robert L UncklessBrian P Lazzaro
May 11, 2016·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Robert L Unckless, Brian P Lazzaro
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Apr 20, 2021·G3 : Genes - Genomes - Genetics·Jamilla Akhund-ZadeBenjamin L de Bivort

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Methods Mentioned

BETA
Protein Assay

Software Mentioned

R
SAS
GOWINDA
GO Slim

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