The complex genetics in autism spectrum disorders

Science China. Life Sciences
Rui HuaChen Zhang

Abstract

Autism spectrum disorders (ASD) are a pervasive neurodevelopmental disease characterized by deficits in social interaction and nonverbal communication, as well as restricted interests and stereotypical behavior. Genetic changes/heritability is one of the major contributing factors, and hundreds to thousands of causative and susceptible genes, copy number variants (CNVs), linkage regions, and microRNAs have been associated with ASD which clearly indicates that ASD is a complex genetic disorder. Here, we will briefly summarize some of the high-confidence genetic changes in ASD and their possible roles in their pathogenesis.

References

Sep 1, 1977·Journal of Child Psychology and Psychiatry, and Allied Disciplines·S Folstein, M Rutter
Dec 1, 1992·Journal of Autism and Developmental Disorders·F R Volkmar
May 1, 1989·Journal of Child Psychology and Psychiatry, and Allied Disciplines·S SteffenburgM Bohman
Feb 1, 1989·Journal of Medical Genetics·M PembreyM Super
Jan 1, 1986·American Journal of Medical Genetics·R J HagermanM Braden
Jan 1, 1985·The American Journal of Psychiatry·E R RitvoA M Ritvo
Jan 1, 1995·Psychological Medicine·A BaileyM Rutter
Aug 1, 1994·Journal of Autism and Developmental Disorders·P BakerS Patil
Jul 1, 1994·Journal of Child Psychology and Psychiatry, and Allied Disciplines·P BoltonM Rutter
Aug 1, 1994·Developmental Medicine and Child Neurology·S BundeyJ A Corbett
Mar 15, 1994·American Journal of Medical Genetics·D SpikerC Chiotti
May 1, 1993·Acta Psychiatrica Scandinavica·L H RolfH Kehrer
Apr 15, 1997·Proceedings of the National Academy of Sciences of the United States of America·G E HomanicsR W Olsen
Jul 1, 1997·Brain Research. Molecular Brain Research·H A Rohan de SilvaA J Patel
Jun 10, 1998·Brain : a Journal of Neurology·A BaileyP Lantos
Oct 29, 1998·Cellular and Molecular Life Sciences : CMLS·E H CorderH Mori
Nov 14, 1998·Journal of Autism and Developmental Disorders·P SzatmariJ E MacLean
Nov 24, 1999·Genomics·A Ashley-KochM A Pericak-Vance
Nov 22, 2000·Neuron·E MaestriniA Bailey
Jan 6, 2001·Neuron·C LordD G Amaral
Apr 24, 2001·Molecular Psychiatry·A M PersicoUNKNOWN Collaborative Linkage Study of Autism
Oct 5, 2001·Nature Reviews. Genetics·B S Emanuel, T H Shaikh
Nov 10, 2001·Annual Review of Genomics and Human Genetics·R D Nicholls, J L Knepper
Dec 6, 2001·Nature Reviews. Genetics·S E Folstein, B Rosen-Sheidley
Jan 30, 2002·Journal of Autism and Developmental Disorders·G J BlattM L Bauman
Mar 29, 2002·Molecular Psychiatry·J D BuxbaumR Vitale
Jul 3, 2002·Journal of Neurogenetics·M M MenoldJ R Gilbert
Oct 18, 2002·Human Genetics·Kim S BeyerUNKNOWN International Molecular Genetic Study of Autism Consortium (IMGSAC)
Apr 2, 2003·Nature Genetics·Stéphane JamainUNKNOWN Paris Autism Research International Sibpair Study
Apr 3, 2003·Neuron·Flavio KamenetzRoberto Malinow
May 29, 2003·Pediatric Neurology·Regina M CarneyMargaret A Pericak-Vance
Jun 27, 2003·Nature·Markus MisslerThomas C Südhof
Dec 4, 2003·Médecine sciences : M/S·Stéphane JamainThomas Bourgeron

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Citations

Apr 11, 2020·Computational and Mathematical Methods in Medicine·Yanhui WangDazhi Meng

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