The complex genomic basis of rapid convergent adaptation to pesticides across continents in a fungal plant pathogen.

Molecular Ecology
Fanny E HartmannDaniel Croll

Abstract

Convergent evolution leads to identical phenotypic traits in different species or populations. Convergence can be driven by standing variation allowing selection to favour identical alleles in parallel or the same mutations can arise independently. However, the molecular basis of such convergent adaptation remains often poorly resolved. Pesticide resistance in agricultural ecosystems is a hallmark of convergence in phenotypic traits. Here, we analyse the major fungal pathogen Zymoseptoria tritici causing serious losses on wheat and with fungicide resistance emergence across several continents. We sampled three population pairs each from a different continent spanning periods early and late in the application of fungicides. To identify causal loci for resistance, we combined knowledge from molecular genetics work and performed genome-wide association studies (GWAS) on a global set of isolates. We discovered yet unknown factors in azole resistance including a gene encoding membrane associated functions. We found strong support for the "hotspot" model of resistance evolution with convergent changes in a small set of loci but additional loci showed more population-specific allele frequency changes. Genome-wide scans of selection sh...Continue Reading

References

Apr 1, 1998·Bioinformatics·D H Huson
Dec 18, 2004·Neuron·Masaki FukataDavid S Bredt
Dec 13, 2006·Nature Genetics·Sarah A TishkoffPanos Deloukas
Dec 22, 2006·Nature Reviews. Molecular Cell Biology·Maurine E Linder, Robert J Deschenes
Jun 26, 2007·Bioinformatics·Peter J BradburyEdward S Buckler
Nov 21, 2007·Trends in Ecology & Evolution·Jeff Arendt, David Reznick
Oct 4, 2008·Pest Management Science·Stefano Ff TorrianiHelge Sierotzki
Mar 3, 2010·Annual Review of Plant Biology·Stephen B Powles, Qin Yu
Jun 10, 2011·Bioinformatics·Petr DanecekUNKNOWN 1000 Genomes Project Analysis Group
Jul 7, 2011·Evolution; International Journal of Organic Evolution·Jonathan B Losos
Mar 6, 2012·Nature Methods·Ben Langmead, Steven L Salzberg
Apr 14, 2012·Nature·Matthew C FisherSarah J Gurr
Jun 23, 2012·Nature·UNKNOWN Heliconius Genome Consortium
Apr 27, 2013·Evolution; International Journal of Organic Evolution·Arnaud Martin, Virginie Orgogozo
Jul 9, 2013·Trends in Genetics : TIG·Christophe DélyeValérie Le Corre
Oct 10, 2013·Nature Reviews. Genetics·David L Stern
Mar 19, 2014·Molecular Ecology·Marius RoestiDaniel Berner
Apr 4, 2014·Bioinformatics·Anthony M BolgerBjoern Usadel
Apr 18, 2014·Molecular Biology and Evolution·Bastian PfeiferMartin J Lercher
Oct 17, 2014·Journal of Chemical Biology·Josie E ParkerSteven L Kelly
Feb 1, 2008·Evolutionary Applications·Jeremy J Burdon, Peter H Thrall
Jan 18, 2015·Advances in Applied Microbiology·John A LucasBart A Fraaije
Jun 21, 2015·Fungal Genetics and Biology : FG & B·Stefano F F TorrianiMikaël Courbot
Aug 21, 2015·Journal of Agricultural and Food Chemistry·Maria-Manuel AzevedoAcácio Gonçalves Rodrigues
Nov 20, 2016·Molecular Ecology·Norfarhan Mohd-AssaadDaniel Croll
Nov 20, 2016·Molecular Ecology Resources·Mathieu GautierRenaud Vitalis

❮ Previous
Next ❯

Related Concepts

Related Feeds

Antifungals

An antifungal, also known as an antimycotic medication, is a pharmaceutical fungicide or fungistatic used to treat and prevent mycosis such as athlete's foot, ringworm, candidiasis, cryptococcal meningitis, and others. Discover the latest research on antifungals here.