The complex history of a gene proposed to participate in a sexual isolation mechanism in house mice

Molecular Biology and Evolution
Robert C KarnPierre Boursot

Abstract

Previous behavioral experiments showed that mouse salivary androgen-binding protein (ABP) was involved in interindividual recognition and might play a role in sexual isolation between house mouse (Mus musculus) subspecies. The pattern of evolution of Abpa, the gene for the alpha subunit of ABP, was found to be consistent with this hypothesis. Abpa apparently diverged rapidly between species and subspecies with a large excess of nonsynonymous substitutions, a lack of exon polymorphism within each of the three subspecies, and a lack of intron polymorphism in the one subspecies studied (M. musculus domesticus). Here we characterized the intron and exon sequence variations of this gene in house mouse populations from central Eurasia, a region yet unsampled and thought to be close to the cradle of the radiation of the subspecies. We also determined the intron and exon sequences in seven other species of the genus Mus. We confirmed the general pattern of rapid evolution by essentially nonsynonymous substitutions, both inter- and intraspecifically, supporting the idea that Darwinian selection has driven the evolution of this gene. We also observed a uniform intron sequence in five samples of M. musculus musculus, suggesting that a sel...Continue Reading

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Citations

Dec 21, 2002·Trends in Genetics : TIG·Jean Louis Guénet, François Bonhomme
Jul 17, 2004·Genome Research·Richard D EmesChris P Ponting
Feb 14, 2008·BMC Evolutionary Biology·Christina M LaukaitisRobert C Karn
Feb 9, 2007·Genetics·John F Baines, Bettina Harr
Sep 16, 2008·Behavioural Processes·B BímováJ Piálek
Apr 28, 2011·Molecular Ecology·Barbora Vošlajerová BímováJaroslav Piálek
Jul 30, 2005·Molecular Phylogenetics and Evolution·Artyom KoppJeffrey Fu
Dec 6, 2002·Nature·UNKNOWN Mouse Genome Sequencing ConsortiumEric S Lander
Aug 22, 2003·Genetics·Noah A Rosenberg, Aaron E Hirsh

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