The complex interplay between autophagy, apoptosis, and necrotic signals promotes T-cell homeostasis.

Immunological Reviews
Craig M Walsh, Aimee L Edinger

Abstract

Intense research efforts over the last two decades have focused on establishing the significance of apoptotic signaling in adaptive immunity. Without doubt, caspase-dependent apoptosis plays vital roles in many immune processes, including lymphocyte development, positive and negative selection, homeostasis, and self-tolerance. Cell biologists have developed new insights into cell death, establishing that other modes of cell death exist, such as programmed necrosis and type II/autophagic cell death. Additionally, immunologists have identified a number of immunological processes that are highly dependent upon cellular autophagy, including antigen presentation, lymphocyte development and function, pathogen recognition and destruction, and inflammatory regulation. In this review, we provide detailed mechanistic descriptions of cellular autophagy and programmed necrosis induced in response to death receptor ligation, including methods to identify them, and compare and contrast these processes with apoptosis. The crosstalk between these three processes is emphasized as newly formulated evidence suggests that this interplay is vital for efficient T-cell clonal expansion. This new evidence indicates that in addition to apoptosis, autop...Continue Reading

References

Jul 10, 1997·Nature·M IrmlerJ Tschopp
Jun 6, 1998·The Journal of Experimental Medicine·D VercammenP Vandenabeele
May 20, 1998·Immunity·C M WalshS M Hedrick
Aug 28, 1998·Science·A Ashkenazi, V M Dixit
Dec 2, 1998·The Journal of Cell Biology·A KawaharaS Nagata
Jul 14, 1999·Immunity·D A HildemanP C Marrack
Dec 22, 1999·The Journal of Experimental Medicine·N J KennedyR C Budd
Sep 20, 2000·The Journal of Cell Biology·Y KamadaY Ohsumi
Dec 2, 2000·Nature·Y IchimuraY Ohsumi
Mar 27, 2001·The Journal of Cell Biology·N MizushimaT Yoshimori
Aug 4, 2001·Molecular and Cellular Biology·M G Vander HeidenC B Thompson
Aug 22, 2001·Trends in Cell Biology·V Baud, M Karin
Jul 18, 2002·Immunity·Kenneth A FrauwirthCraig B Thompson
Nov 15, 2002·Journal of Cell Science·Céline CandéGuido Kroemer
Nov 28, 2002·Molecular Cell·Véronique RolliMichael Reth
Feb 4, 2003·Nature Cell Biology·Josef M Penninger, Guido Kroemer
Mar 26, 2003·Genes & Development·Leonardo SalmenaRazqallah Hakem
Oct 17, 2003·The Journal of Physiology·Julio F Turrens
Nov 7, 2003·Journal of Clinical Immunology·Craig M WalshAdrian F Arechiga
Dec 6, 2003·Proceedings of the National Academy of Sciences of the United States of America·Zhenyu YueNathaniel Heintz
May 7, 2004·The Journal of Immunology : Official Journal of the American Association of Immunologists·Zhengqi WuRichard M Siegel

❮ Previous
Next ❯

Citations

Dec 12, 2012·Archivum Immunologiae Et Therapiae Experimentalis·Wiem ChaabaneMarek J Los
Jul 20, 2012·Archives of Toxicology·José M MatésJavier Márquez
Jun 30, 2012·Cell Death and Differentiation·J Xu, Y-H Li
May 18, 2012·Proceedings of the National Academy of Sciences of the United States of America·Tim Willinger, Richard A Flavell
Feb 15, 2011·Carcinogenesis·Mathias T Rosenfeldt, Kevin M Ryan
Jul 28, 2012·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Cristiano AlessandriMarina Pierdominici
Feb 18, 2011·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Ravi K AmaravadiEileen White
Sep 29, 2011·BMC Genomics·Gerrit TimmerhausSven Martin Jørgensen
Jun 1, 2012·BMC Genomics·Gerrit TimmerhausSven Martin Jørgensen
Dec 14, 2011·Immunotherapy·Shoba Amarnath, Daniel H Fowler
Sep 26, 2013·Reproduction : the Official Journal of the Society for the Study of Fertility·Quanwei WeiFangxiong Shi
Dec 24, 2013·Antioxidants & Redox Signaling·Elena OrtonaMarina Pierdominici
May 27, 2014·Seminars in Immunology·Guy S Salvesen, Craig M Walsh
Jul 22, 2015·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Luciana Nalone AndradeDamião Pergentino de Sousa
Feb 3, 2016·Critical Reviews in Oncology/hematology·Ning-Ning ShanYing Li
Jun 3, 2014·The Journal of Physiology·James A Shapiro
Apr 7, 2015·Mechanisms of Ageing and Development·Ewa Sikora
Dec 17, 2014·Particle and Fibre Toxicology·Marina PierdominiciSilvana Fiorito
Feb 28, 2013·Journal of Cellular Physiology·Alberto RicciSalvatore Mariotta
Jul 20, 2010·Immunological Reviews·Philippa MarrackMegan K L MacLeod
Jun 28, 2011·Biochimica Et Biophysica Acta·Bram J van Raam, Guy S Salvesen
May 12, 2015·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Qingjun PanHua-feng Liu
Apr 26, 2013·Autophagy·Saurabh Ghosh RoyAimee L Edinger
Mar 5, 2013·Phytomedicine : International Journal of Phytotherapy and Phytopharmacology·Rosana P C FerrazDaniel P Bezerra
Feb 5, 2013·Toxicology in Vitro : an International Journal Published in Association with BIBRA·R P KerrR M Gogal
Aug 25, 2015·PloS One·Emma L ReuschelTerri H Finkel
Jul 28, 2017·The Journal of Immunology : Official Journal of the American Association of Immunologists·Jie DangQiji Liu
Jan 1, 2013·Journal of Cell Death·Abdelouahid El-KhattoutiMohamed Hassan
Jan 28, 2015·Infection and Immunity·Catriona T PrendergastAdrian P Mountford
Jan 12, 2019·Biomaterials Science·Brynn R OldenSuzie H Pun
Dec 22, 2019·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Carla Cardozo Pinto de ArrudaKátia da Silva Calabrese
Jan 17, 2012·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Marina PierdominiciElena Ortona
Nov 16, 2017·Molecular Medicine Reports·Yang-Hua TangCan-Da Xu
Dec 25, 2019·Journal of Immunology Research·Fangyuan YangErwei Sun

❮ Previous
Next ❯

Related Concepts

Related Feeds

Autophagy & Model Organisms

Autophagy is a cellular process that allows degradation by the lysosome of cytoplasmic components such as proteins or organelles. Here is the latest research on autophagy & model organisms

Apoptosis

Apoptosis is a specific process that leads to programmed cell death through the activation of an evolutionary conserved intracellular pathway leading to pathognomic cellular changes distinct from cellular necrosis