The complex relationship between cell division and the control of differentiation in oligodendrocyte-type-2 astrocyte progenitor cells isolated from perinatal and adult rat optic nerves

Progress in Growth Factor Research
M NobleD R Wren

Abstract

By studying the response of a well-defined progenitor cell to two well-defined mitogens, we have been able to provide a dramatic example of the complex relationships which can exist between the control of cell division and the control of differentiation. In previous studies we have described the development of the oligodendrocyte-type-2 astrocyte (O-2A) progenitor cell, a glial progenitor cell isolated from the rat optic nerve. Although originally described as a bipotential cell, we have recently identified a new differentiation pathway in this lineage. We have found that O-2Aperinatal progenitors, with properties appropriate for early development, give rise to O-2Aadult progenitors, which have stem cell-like properties more appropriate to the physiological needs of adult animals. Our studies thus indicate that the population of O-2Aperinatal progenitors is tripotential, and also suggests a possible developmental origin for self-renewing stem cells. Moreover, the properties of O-2Aadult progenitor cells may provide a cellular biological basis for understanding the failure of remyelination in multiple sclerosis. The division of both O-2Aperinatal and O-2Aadult progenitors is stimulated by type-1 astrocytes (which are themselves ...Continue Reading

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Citations

Jun 1, 1992·Developmental Biology·G J Graham, I B Pragnell
Nov 26, 1999·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·M ChekenyaG J Pilkington
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Mar 19, 2016·Experimental Neurology·Hülya KıraySusan C Barnett
Jan 1, 1997·Molecular and Cellular Neurosciences·T D PalmerF H Gage
Mar 4, 2014·Progress in Neurobiology·Jason R PlemelWolfram Tetzlaff
Mar 25, 2008·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·Kidsadagon PringproaKonstantin Wewetzer

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