The Complex Relationship between Metals and Carbonic Anhydrase: New Insights and Perspectives

International Journal of Molecular Sciences
Maria Giulia LionettoTrifone Schettino

Abstract

Carbonic anhydrase is a ubiquitous metalloenzyme, which catalyzes the reversible hydration of CO₂ to HCO₃(-) and H⁺. Metals play a key role in the bioactivity of this metalloenzyme, although their relationships with CA have not been completely clarified to date. The aim of this review is to explore the complexity and multi-aspect nature of these relationships, since metals can be cofactors of CA, but also inhibitors of CA activity and modulators of CA expression. Moreover, this work analyzes new insights and perspectives that allow translating new advances in basic science on the interaction between CA and metals to applications in several fields of research, ranging from biotechnology to environmental sciences.

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Citations

Dec 29, 2017·Chemistry, an Asian Journal·Min-Chul Kim, Sang-Yup Lee
Oct 5, 2018·Journal of Enzyme Inhibition and Medicinal Chemistry·Giannamaria AnnunziatoGabriele Costantino
Apr 27, 2019·The ISME Journal·Erik L JensenBrigitte Gontero
Nov 16, 2018·Scientific Reports·Tom BiscéréFanny Houlbrèque
Apr 26, 2020·International Journal of Molecular Sciences·Erik L JensenBrigitte Gontero
May 5, 2017·Dalton Transactions : an International Journal of Inorganic Chemistry·Bartosz MarzecWolfgang Schmitt
May 24, 2020·International Journal of Molecular Sciences·Maria Giulia LionettoMaria Elena Giordano
Jul 3, 2018·Frontiers in Neuroscience·Dirk RoostermanGraeme S Cottrell
Mar 30, 2021·Bulletin of Environmental Contamination and Toxicology·Emiliano Bálsamo Crespo, Gustavo Bulus Rossini
Mar 2, 2019·Environmental Science & Technology·Mariateresa AlloccaClaudia Tortiglione
Aug 28, 2021·International Journal of Molecular Sciences·Erik L JensenHélène Launay
Dec 11, 2021·Expert Review of Proteomics·Paul DowlingKay Ohlendieck

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