The Complex Role of Neutrophils in Tumor Angiogenesis and Metastasis

Cancer Immunology Research
Wei Liang, Napoleone Ferrara

Abstract

Chronic inflammation fosters cancer development and progression and also modulates tumor responses to anticancer therapies. Neutrophils are key effector cells in innate immunity and are known to play a critical role in various inflammatory disorders. However, the functions of neutrophils in cancer pathogenesis have been largely neglected until recently and still remain poorly characterized compared with other immune cells in the tumor microenvironment. We highlight recent findings on the mechanisms by which tumor cells, in cooperation with tumor-associated stromal cells, induce expansion, recruitment, and polarization of neutrophils. We also review the multifaceted roles that neutrophils play in different aspects of cancer development and progression, with an emphasis on tumor angiogenesis and metastasis.

References

Sep 1, 1990·Proceedings of the National Academy of Sciences of the United States of America·D B DubravecM L Rodrick
Sep 25, 1995·FEBS Letters·S HannahE R Chilvers
Nov 1, 1996·Chemistry & Biology·L M Coussens, Z Werb
May 4, 1999·The Journal of Clinical Investigation·W G Stetler-Stevenson
Jul 10, 1999·Advances in Immunology·M A Cassatella
Sep 29, 1999·Acta Neuropathologica·G FossatiM L Rossi
Feb 24, 2001·Virchows Archiv : an International Journal of Pathology·T MentzelC D Fletcher
Mar 7, 2001·Lancet·F Balkwill, A Mantovani
Aug 9, 2002·Oral Oncology·E JablonskaZ Grabowska
Oct 3, 2002·Nature Reviews. Cancer·Napoleone Ferrara
Jun 13, 2003·Molecular Biology of the Cell·Richard C Bates, Arthur M Mercurio
Jan 5, 2005·The Journal of Experimental Medicine·Sarah R WalmsleyEdwin R Chilvers
Jul 16, 2005·Growth Factors·Andrew W Roberts
Aug 2, 2005·Nature Reviews. Immunology·Vincenzo Bronte, Paola Zanovello
Aug 25, 2005·Journal of Surgical Oncology·S R WalshN J Keeling
Feb 24, 2006·Proceedings of the National Academy of Sciences of the United States of America·Taro TamadaRyota Kuroki
Jul 28, 2006·Mutagenesis·Ad M KnaapenFrederik J Van Schooten
Aug 8, 2006·Proceedings of the National Academy of Sciences of the United States of America·Hiroaki NozawaDouglas Hanahan
May 4, 2007·The Journal of Immunology : Official Journal of the American Association of Immunologists·Margaret L HibbsAshley R Dunn
Jul 14, 2007·Trends in Immunology·Niels BorregaardKim Theilgaard-Mönch
Aug 1, 2007·Nature Biotechnology·Farbod ShojaeiNapoleone Ferrara
Dec 8, 2007·Nature·Farbod ShojaeiNapoleone Ferrara
Dec 14, 2007·Proceedings of the National Academy of Sciences of the United States of America·Veronica C ArdiJames P Quigley
Apr 9, 2008·Neoplasia : an International Journal for Oncology Research·Jessica C PahlerDouglas Hanahan
Apr 2, 2009·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Cuiling ZhongNapoleone Ferrara
Apr 7, 2009·Proceedings of the National Academy of Sciences of the United States of America·Farbod ShojaeiNapoleone Ferrara
Jun 3, 2009·The Journal of Clinical Investigation·Raghu Kalluri, Robert A Weinberg
Nov 6, 2009·Blood·Martin PelletierMarco A Cassatella
Jan 19, 2010·Nature Medicine·A McGarry HoughtonSteven D Shapiro
Mar 20, 2010·The Journal of Clinical Investigation·Jadwiga JablonskaSiegfried Weiss
Jun 29, 2010·Blood·Huiyuan ZhangStephanie S Watowich
Jul 21, 2010·The Journal of Immunology : Official Journal of the American Association of Immunologists·Melissa G LechnerAlan L Epstein

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Citations

Mar 16, 2016·Seminars in Immunology·Catharina Hagerling, Zena Werb
Mar 30, 2016·Cytokine & Growth Factor Reviews·Ornella BonavitaRaffaella Bonecchi
Mar 31, 2016·Nature Cell Biology·Edward L LaGory, Amato J Giaccia
Apr 14, 2016·Seminars in Immunology·Katrin Moses, Sven Brandau
May 9, 2016·Irish Journal of Medical Science·A KornilukV Dymicka-Piekarska
Aug 26, 2016·Immunological Reviews·Patrizia ScapiniMarco A Cassatella
Sep 13, 2016·Vaccines·Serena Zilio, Paolo Serafini
Feb 9, 2017·International Journal of Cancer. Journal International Du Cancer·Sara NajmehJonathan D Spicer
Jul 15, 2017·Nature Reviews. Cancer·Michele De PalmaTatiana V Petrova
Mar 13, 2018·Nanoscale·Pravin BhattaraiZhifei Dai
Aug 25, 2017·Acta Oncologica·Antoine SchernbergEric Deutsch
Nov 11, 2017·Cancer Growth and Metastasis·Kim DonatiDidier Cataldo
Sep 7, 2018·Journal of Ocular Pharmacology and Therapeutics : the Official Journal of the Association for Ocular Pharmacology and Therapeutics·Adrian Will-OrregoStephen H Poor
Oct 12, 2018·Proceedings of the National Academy of Sciences of the United States of America·Wei LiangNapoleone Ferrara
Jan 30, 2019·Future Oncology·Pingping HuJiandong Zhang
Feb 12, 2019·Annual Review of Physiology·Massimiliano Mazzone, Gabriele Bergers
Mar 16, 2019·Journal of Internal Medicine·A MantovaniS Jaillon
Dec 13, 2018·Angiogenesis·Nicholas J ProtopsaltisNapoleone Ferrara
Jun 24, 2017·Medicinal Research Reviews·Roberto RoncaSandra Liekens
Oct 2, 2019·Frontiers in Immunology·Yichao Hua, Gabriele Bergers
Nov 28, 2019·Expert Review of Gastroenterology & Hepatology·Yan LvHai-Jun Zhang
Apr 23, 2017·Oncotarget·Jiu-Ming ZouZuo-Hua Feng
Dec 13, 2017·Oncotarget·José M García-Heredia, Amancio Carnero
Nov 9, 2018·Oncology Letters·Jayra Juliana Paiva AlvesJosé Veríssimo Fernandes
Aug 5, 2020·The Journal of Clinical Investigation·Vincent Wai-Hin Yuen, Carmen Chak-Lui Wong
Oct 19, 2016·Current Opinion in Hematology·Cédric Seignez, Mia Phillipson
Aug 26, 2016·Immunological Reviews·Eric L CampbellSean P Colgan

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