PMID: 3320567Jan 1, 1987Paper

The complexity of anti-estrogen responses

Journal of Steroid Biochemistry
J R PasqualiniB L Nguyen

Abstract

The actions and biological responses of anti-estrogens are a function of: the experimental conditions, the parameters, the organ and the animal species considered. Target tissues for estrogens in the guinea-pig during the perinatal period are interesting models to explore the action of anti-estrogens. The summary of the data indicates: (1) In the fetal uterus of guinea-pig in in vivo experiments (after injection to the maternal compartment) tamoxifen acts as a real agonist concerning growth, as a partial agonist concerning the stimulation of the progesterone receptor. (2) In in vitro experiments (in organ culture of fetal uterus or in isolated cells) anti-estrogens (tamoxifen or 4-hydroxy-tamoxifen) act as antagonists and also inhibit the effects provoked by estrogens. (3) In the uterus and vagina of newborn guinea-pigs, tamoxifen and its derivatives: 4-hydroxytamoxifen and N-desmethyltamoxifen act as real agonists concerning the uterotrophic and vaginotrophic effects, and also stimulate the amount of DNA per organ, but concerning the progesterone receptor in the uterus, in the short treatment anti-estrogens act as partial agonists but they have no effect in the long treatment. In the vagina in the short treatment anti-estrogen...Continue Reading

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Citations

Jun 1, 1994·Biochemical Pharmacology·C D van den KoedijkJ H Thijssen
Sep 1, 1991·The Journal of Steroid Biochemistry and Molecular Biology·M C LopesA P Carvalho
Dec 1, 1991·Journal of Neurobiology·G A Mathews, A P Arnold
Sep 1, 1989·Prostaglandins, Leukotrienes, and Essential Fatty Acids·P Peplow, J Y Jeremy
Nov 1, 1988·Journal of Endocrinological Investigation·F Sciarra

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