The Complexity of Mitochondrial Complex IV: An Update of Cytochrome c Oxidase Biogenesis in Plants

International Journal of Molecular Sciences
Natanael MansillaElina Welchen

Abstract

Mitochondrial respiration is an energy producing process that involves the coordinated action of several protein complexes embedded in the inner membrane to finally produce ATP. Complex IV or Cytochrome c Oxidase (COX) is the last electron acceptor of the respiratory chain, involved in the reduction of O₂ to H₂O. COX is a multimeric complex formed by multiple structural subunits encoded in two different genomes, prosthetic groups (heme a and heme a₃), and metallic centers (CuA and CuB). Tens of accessory proteins are required for mitochondrial RNA processing, synthesis and delivery of prosthetic groups and metallic centers, and for the final assembly of subunits to build a functional complex. In this review, we perform a comparative analysis of COX composition and biogenesis factors in yeast, mammals and plants. We also describe possible external and internal factors controlling the expression of structural proteins and assembly factors at the transcriptional and post-translational levels, and the effect of deficiencies in different steps of COX biogenesis to infer the role of COX in different aspects of plant development. We conclude that COX assembly in plants has conserved and specific features, probably due to the incorpora...Continue Reading

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Citations

Sep 1, 2018·Protein Science : a Publication of the Protein Society·Liezelle C LopezLaura M Hunsicker-Wang
Jan 15, 2020·Plant Signaling & Behavior·Xiao-Ting ZhaiBing Li
Dec 18, 2019·Journal of Nursing Management·Mi-Aie LeeSo-Hee Lim
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Feb 20, 2019·Plant Molecular Biology·Lucila GarciaDaniel H Gonzalez
Sep 11, 2020·Plant Molecular Biology·Michail MichailidisAthanassios Molassiotis
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Dec 29, 2020·Journal of Experimental Botany·Elina WelchenDaniel H Gonzalez
Jan 14, 2021·International Journal of Molecular Sciences·Margherita Protasoni, Massimo Zeviani
Dec 9, 2020·Biomedicines·Jake J WenRavi S Radhakrishnan
Mar 13, 2021·Neurology. Genetics·Giacomo SferruzzaMarina Scarlato
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Nov 19, 2021·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Maureen Yin, Luke A J O'Neill

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Methods Mentioned

BETA
Electrophoresis

Software Mentioned

Genevestigator
MEME

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