PMID: 9555113Apr 29, 1998Paper

The complexity of the Epstein-Barr virus infection in humans

Pathology Oncology Research : POR
E Klein

Abstract

The Epstein-Barr virus (EBV) was isolated 40 years ago from cultures of Burkitt lymphoma cells (BL). The tumor was encountered in Africa and exhibited characteristical geographical, clinical and pathological features. Serological studies revealed that the virus is ubiquitous in humans. The primary infection is often accompanied by the syndrome of acute infectious mononucleosis (IM). It can induce malignant proliferation of B lymphocytes in conditions of immunodeficiency. EBV can immortalize B lymphocytes in culture. These cells carry the virus as episomes and express 9 virally encoded proteins. Their immunological recognition constitutes the surveillance which is responsible for the healthy virus carrier state. The main virus reservoir is represented by a low number of resting B lymphocyte which contain the viral genome but do not express its transformation proteins. The viral genome is detectable in all African BLs, in variable proportions of nasopharyngeal carcinoma, Hodgkin's disease, T cell lymphoma, lymphoepithelial like carcinoma, gastric carcinoma and leiomyosarcoma cases. The role of EBV in the genesis of these tumors is unknown.

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Citations

Sep 15, 2000·Infectious Disease Clinics of North America·J D Fingeroth
Dec 25, 2003·Journal of Virology·Rachel H EdwardsNancy Raab-Traub
Jul 3, 2002·Pathology, Research and Practice·María Victoria PreciadoElena De Matteo
Jan 4, 2007·Cytometry. Part a : the Journal of the International Society for Analytical Cytology·Jie Liu, Mario Roederer
Apr 16, 2009·Headache·Frederick R Taylor
Apr 1, 2015·American Journal of Health-system Pharmacy : AJHP : Official Journal of the American Society of Health-System Pharmacists·Charles Edward Daniels
Jan 6, 2000·Journal of Healthcare Risk Management : the Journal of the American Society for Healthcare Risk Management·G E KnoxD Berry
Oct 24, 2009·Journal of Materials Science. Materials in Medicine·Robin S WaltonJan T Czernuszka
Nov 12, 2007·Cognitive Science·Alexandre Linhares, Paulo Brum
Jul 13, 2006·European Journal of Cancer Prevention : the Official Journal of the European Cancer Prevention Organisation (ECP)·Hugo SousaRui Medeiros
Mar 7, 2012·Journal of Clinical Gastroenterology·Jian-Ning ChenChun-Kui Shao
Nov 25, 2000·Clinical Transplantation·A ShimizuN Yamanaka
Sep 29, 2006·World Journal of Gastroenterology : WJG·Mihaela PetrovaZahariy Krastev

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