The composition of the pulmonary microbiota in sarcoidosis - an observational study

Respiratory Research
André BeckerRobert Bals

Abstract

Sarcoidosis is a systemic disease of unknown etiology. The disease mechanisms are largely speculative and may include the role microbial patterns that initiate and drive an underlying immune process. The aim of this study was to characterize the microbiota of the lung of patients with sarcoidosis and compare its composition and diversity with the results from patients with other interstitial lung disease (ILD) and historic healthy controls. Patients (sarcoidosis, n = 31; interstitial lung disease, n = 19) were recruited within the PULMOHOM study, a prospective cohort study to characterize inflammatory processes in pulmonary diseases. Bronchoscopy of the middle lobe or the lingula was performed and the recovered fluid was immediately sent for analysis of the pulmonary microbiota by 16sRNA gene sequencing. Subsequent bioinformatic analysis was performed to compare the groups. There were no significant differences between patients with sarcoidosis or other ILDs with regard to microbiome composition and diversity. In addition, the abundance of the genera Atopobium, Fusobacterium, Mycobacterium or Propionibacterium were not different between the two groups. There were no gross differences to historical healthy controls. The analysis...Continue Reading

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Citations

May 30, 2019·International Journal of Molecular Sciences·Marcin WłodarczykMarek Fol
Aug 16, 2019·Expert Review of Respiratory Medicine·David BennettPaola Rottoli
Jun 12, 2019·Journal of Biomedical Science·Pleiades T InaokaJ Luis Espinoza
Apr 16, 2020·Journal of Clinical Medicine·Rashi JainJun-O Jin
Nov 11, 2020·Virchows Archiv : an International Journal of Pathology·Stijn E VerledenDanny Jonigk

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Methods Mentioned

BETA
PCRs
PCA

Software Mentioned

BLASTn
MultiQC
package “
Krona
ALDEx2
package coin
zCompositions ”
BLAST
EDirect
LotuS

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