The computational sperm cell

Trends in Cell Biology
Luis AlvarezU Benjamin Kaupp

Abstract

Sperm are guided to the egg by a gradient of chemical attractants - a process called chemotaxis. The binding of the chemoattractant to receptors on the surface of the flagellum triggers a cascade of signaling events that eventually lead to an influx of Ca(2+) ions. Based on these Ca(2+) surges, which control the waveform of the flagellar beat, sperm adjust their swimming path toward the egg. In past years, many components of chemotactic signaling have been identified. Moreover, kinetic spectroscopy and imaging techniques unraveled the sequence of cellular events controlling swimming behavior. During navigation in a chemical gradient, sperm perform a surprising variety of computational operations. Here we discuss theoretical concepts of navigation strategies and the cellular underpinnings.

References

Nov 1, 1977·Biophysical Journal·H C Berg, E M Purcell
Jul 1, 1992·Proceedings of the National Academy of Sciences of the United States of America·D F BabcockA Darszon
Jan 1, 1991·Cell Motility and the Cytoskeleton·C B LindemannK S Kanous
Jan 1, 1988·Cell Motility and the Cytoskeleton·C B Lindemann, J S Goltz
Dec 1, 1985·The Journal of Cell Biology·G E WardV D Vacquier
Mar 1, 1984·Journal of Reproduction and Fertility·H WinetJ Head
Jun 8, 2001·Biochemical and Biophysical Research Communications·T NishigakiA Darszon
Jun 27, 2001·Applied and Environmental Microbiology·R Thar, T Fenchel
May 11, 2002·Science·Tom Fenchel
May 16, 2002·Proceedings of the National Academy of Sciences of the United States of America·Yi-Hsien Su, Victor D Vacquier
Nov 27, 2002·Cell Motility and the Cytoskeleton·J CossonC Gagnon
Feb 4, 2003·Nature Cell Biology·U Benjamin KauppIngo Weyand
Jul 31, 2003·Reproduction : the Official Journal of the Society for the Study of Fertility·D M Woolley
Aug 19, 2003·Developmental Biology·Midori MatsumotoIngo Weyand
Jun 2, 2005·The Journal of Cell Biology·Christopher D WoodAlberto Darszon
Jun 28, 2005·Gene·Mamoru NomuraVictor D Vacquier
Jul 8, 2005·The EMBO Journal·Martin BöhmerUlrich Benjamin Kaupp
Oct 21, 2005·Molecular Biology of the Cell·Yi-Hsien Su, Victor D Vacquier
Oct 26, 2005·Proceedings of the National Academy of Sciences of the United States of America·Daniela NicastroWolfgang Baumeister
Apr 12, 2006·Nature Reviews. Molecular Cell Biology·Michael Eisenbach, Laura C Giojalas
Jun 27, 2006·FEBS Letters·Herath Jayantha Gunaratne, Victor D Vacquier
Aug 19, 2006·Science·Daniela NicastroJ Richard McIntosh
Sep 2, 2006·Annual Review of Physiology·Matthias Salathe
Sep 12, 2006·Nature Cell Biology·Timo StrünkerU Benjamin Kaupp
Jan 27, 2007·Biochemical and Biophysical Research Communications·Blanca Estela GalindoAlberto Darszon
May 23, 2007·Proceedings of the National Academy of Sciences of the United States of America·Dan WangDavid L Garbers
Aug 10, 2007·Proceedings of the National Academy of Sciences of the United States of America·Benjamin M Friedrich, Frank Jülicher
Nov 9, 2007·Annual Review of Physiology·U Benjamin KauppIngo Weyand
Jun 17, 2008·Biochemical and Biophysical Research Communications·G CorkidiA Darszon
Jul 24, 2008·The International Journal of Developmental Biology·Susan S Suarez
Sep 4, 2008·Physical Review Letters·Allison P BerkeEric Lauga
Nov 21, 2008·Nature·Gáspár JékelyDetlev Arendt
Dec 3, 2008·Proceedings of the National Academy of Sciences of the United States of America·Kogiku ShibaManabu Yoshida
Aug 14, 2009·Journal of the Royal Society, Interface·Takuji Ishikawa
Sep 2, 2009·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Gáspár Jékely
Oct 2, 2009·Physical Review Letters·Benjamin M Friedrich, Frank Jülicher
Oct 29, 2009·Science Signaling·Wolfgang BönigkU Benjamin Kaupp
Mar 3, 2010·Annual Review of Biophysics·Kristen F SwaneyPeter N Devreotes

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Citations

Jan 17, 2016·Biochimica Et Biophysica Acta·Juan García-RincónCarmen Beltrán
Aug 20, 2014·The Journal of Cell Biology·Magdalena PichloUrsel Collienne
Feb 4, 2016·Scientific Reports·James G H WhitingAndrew Adamatzky
Dec 15, 2015·Proceedings of the National Academy of Sciences of the United States of America·Anton BukatinVasily Kantsler
Nov 7, 2015·Journal of Theoretical Biology·Kenta IshimotoEamonn A Gaffney
Nov 17, 2015·Integrative Biology : Quantitative Biosciences From Nano to Macro·G Pezzulo, M Levin
Jul 30, 2014·Biochimica Et Biophysica Acta·Victor D VacquierCarmen Beltrán
Mar 15, 2015·Current Opinion in Neurobiology·T StrünkerU B Kaupp
Aug 19, 2015·Nature Communications·Jan F JikeliU Benjamin Kaupp
May 1, 2015·Asian Journal of Andrology·Dickson D Varner
May 28, 2015·Biomicrofluidics·H A GuidobaldiV I Marconi
Apr 17, 2015·Journal of the Royal Society, Interface·Kenta Ishimoto, Eamonn A Gaffney
Apr 4, 2015·The Journal of Chemical Physics·Andreas KaiserHartmut Löwen
Jun 13, 2015·Royal Society Open Science·E H OoiJ Kirkman-Brown
Jul 23, 2016·Frontiers in Psychology·František Baluška, Michael Levin
Aug 18, 2016·The Journal of Physical Chemistry Letters·Nobuhiko J SuematsuSatoshi Nakata
Nov 9, 2016·Trends in Cell Biology·U B Kaupp, T Strünker
Jan 14, 2017·Soft Matter·Jonathan Tammo SiebertPeter Virnau
Feb 1, 2017·PLoS Computational Biology·Richard John Wheeler
Mar 31, 2017·Journal of Plant Research·Luis Alvarez
Apr 20, 2018·PLoS Computational Biology·Justus A KromerBenjamin M Friedrich
Nov 11, 2017·Nature Communications·Guglielmo SaggioratoJens Elgeti
Dec 16, 2017·Journal of Physics. Condensed Matter : an Institute of Physics Journal·Chenyu JinCorinna C Maass
Nov 2, 2017·Nature Reviews. Urology·Reza NosratiDavid Sinton
Jun 2, 2018·Small·Klaas BenteDamien Faivre
May 4, 2018·British Journal of Pharmacology·Andreas RennhackTimo Strünker
Oct 9, 2014·Integrative Biology : Quantitative Biosciences From Nano to Macro·Taymour M El-SherryMohamed Abdelgawad
Jan 19, 2018·Scientific Reports·Ulrich Dobramysl, David Holcman
Nov 12, 2015·Nature Communications·Reza NosratiDavid Sinton
Feb 23, 2019·The European Physical Journal. E, Soft Matter·Ruma Maity, P S Burada
Jul 10, 2019·Soft Matter·Michael KuronJoost de Graaf
Dec 24, 2014·The EMBO Journal·Reinhard SeifertTimo Strünker
Feb 23, 2019·Science Advances·Meisam ZaferaniAlireza Abbaspourrad
Oct 18, 2019·PLoS Biology·Nicholas T HendersonDaniel J Lew
Dec 31, 2019·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·A GongL Alvarez
Feb 7, 2020·Physiology·David EladDan Grisaru
Feb 15, 2020·Journal of Physics. Condensed Matter : an Institute of Physics Journal·Gerhard GompperSohan Kale
Apr 29, 2015·Reports on Progress in Physics·J ElgetiG Gompper
Mar 3, 2017·The Journal of Chemical Physics·Bram BetRené van Roij
Mar 3, 2017·The Journal of Chemical Physics·D S Grebenkov, J-F Rupprecht
Oct 5, 2018·Evolution Letters·Rowan A LymberyJonathan P Evans
May 31, 2018·Scientific Reports·Hossein Nili, Ali Naji
Feb 20, 2020·Physical Review. E·Andreas FischerThomas Speck
Apr 4, 2020·Physical Review Letters·Justus A KromerBenjamin M Friedrich

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