The concentration-dependent nature of in vitro amphotericin B-itraconazole interaction against Aspergillus fumigatus: isobolographic and response surface analysis of complex pharmacodynamic interactions

International Journal of Antimicrobial Agents
J MeletiadisP E Verweij

Abstract

The interaction between polyenes and azoles is not well understood. We therefore explored the in vitro combination of amphotericin B with itraconazole against 14 clinical Aspergillus fumigatus isolates (9 itraconazole susceptible and 5 itraconazole resistant) with a colorimetric broth microdilution checkerboard technique using two drug interaction models able to explore complicated patterns of interactions: the response surface analysis of Bliss independence and the isobolographic analysis of Loewe additivity zero interaction theories. Synergy was found at combinations with low concentrations of amphotericin B (<0.125 mg/L), whereas antagonism was found at combinations with higher concentrations of amphotericin B. For itraconazole-resistant isolates, synergistic interactions were observed at high concentrations of itraconazole (>0.5 mg/L). Synergy was more frequently observed for the itraconazole-resistant isolates than for the itraconazole-susceptible isolates.

References

Mar 1, 1990·Reviews of Infectious Diseases·H A GallisW W Pickard
Apr 1, 1988·The Journal of Antimicrobial Chemotherapy·M C Berenbaum
Feb 1, 1987·The Journal of Antimicrobial Chemotherapy·M C Berenbaum
Jul 1, 1983·Reviews of Infectious Diseases·G Medoff
Sep 1, 1995·Antimicrobial Agents and Chemotherapy·A M Sugar
Jun 2, 1998·The Journal of Infectious Diseases·A M Sugar, X P Liu
Sep 19, 2000·Antimicrobial Agents and Chemotherapy·D P KontoyiannisK V Rolston
Dec 20, 2000·The Journal of Infection·C B MooreD W Denning
Aug 30, 2001·Journal of Clinical Microbiology·J MeletiadisUNKNOWN EUROFUNG Network
Sep 17, 2003·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·William J SteinbachDavid W Denning
Feb 26, 2004·Antimicrobial Agents and Chemotherapy·Melissa D JohnsonJohn H Rex
Jul 1, 2004·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·H F Miranda, G Pinardi
Jul 28, 2004·Progress in Neuro-psychopharmacology & Biological Psychiatry·Padi S V SatyanarayanaShrinivas K Kulkarni
Sep 18, 2004·Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases·P H ChandrasekarE K Manavathu
Sep 9, 2006·The Journal of Infectious Diseases·Joseph MeletiadisThomas J Walsh

❮ Previous
Next ❯

Citations

Jan 8, 2008·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Thomas J WalshUNKNOWN Infectious Diseases Society of America
May 10, 2008·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Jose A Vazquez
Jul 31, 2007·Future Microbiology·Jose A Vazquez
Oct 5, 2007·Expert Review of Anti-infective Therapy·Brahm H Segal, William J Steinbach
Jul 2, 2016·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Thomas F PattersonJohn E Bennett

❮ Previous
Next ❯

Related Concepts

Related Feeds

Aspergillosis

Aspergillosis is the name given to a wide variety of diseases caused by infection by fungi of the genus Aspergillus. Aspergillosis occurs in chronic or acute forms which are clinically very distinct. Most cases of acute aspergillosis occur in patients with severely compromised immune systems. Chronic colonization or infection can cause complications in people with underlying respiratory illnesses. Discover the latest research on aspergillosis here.

Candidiasis

Candidiasis is a common fungal infection caused by Candida and it can affect many parts for the body including mucosal membranes as well as the gastrointestinal, urinary, and respiratory tracts. Here is the latest research.

Aspergillosis (ASM)

Aspergillosis is the name given to a wide variety of diseases caused by infection by fungi of the genus Aspergillus. Aspergillosis occurs in chronic or acute forms which are clinically very distinct. Most cases of acute aspergillosis occur in patients with severely compromised immune systems. Chronic colonization or infection can cause complications in people with underlying respiratory illnesses. Discover the latest research on aspergillosis here.

Candidiasis (ASM)

Candidiasis is a common fungal infection caused by Candida and it can affect many parts for the body including mucosal membranes as well as the gastrointestinal, urinary, and respiratory tracts. Here is the latest research.

Antifungals (ASM)

An antifungal, also known as an antimycotic medication, is a pharmaceutical fungicide or fungistatic used to treat and prevent mycosis such as athlete's foot, ringworm, candidiasis, cryptococcal meningitis, and others. Discover the latest research on antifungals here.

Candida albicans

Candida albicans is an opportunistic, fungal pathogen of humans that frequently causes superficial infections of oral and vaginal mucosal surfaces of debilitated and susceptible individuals. Discover the latest research on Candida albicans here.

Antifungals

An antifungal, also known as an antimycotic medication, is a pharmaceutical fungicide or fungistatic used to treat and prevent mycosis such as athlete's foot, ringworm, candidiasis, cryptococcal meningitis, and others. Discover the latest research on antifungals here.