The concentration of total sialic acid in chronic hepatitis B and C

Annals of Clinical Biochemistry
Ewa GruszewskaLech Chrostek

Abstract

Background The synthesis and glycosylation of glycoproteins and glycolipids take place in the liver. Thus, liver diseases may affect serum concentrations of some carbohydrate derivatives, especially the concentration of sialic acid which is attached to the end of oligosaccharide chains. The aim of this study was to measure and compare the serum concentration of total sialic acid in chronic hepatitis B and C. The hypothesis is that both viruses responsible for the development of inflammation work differently at the cellular level. Methods Serum samples were obtained from 90 patients suffering from liver diseases: 50 from chronic hepatitis B and 40 from chronic hepatitis C at the time of diagnosis. The total sialic acid concentration in the serum was measured according to the enzymatic method using a colorimetric procedure. Results The mean total sialic acid concentration in patients with chronic hepatitis B was significantly lower than the mean concentration in the healthy group, while in patients with chronic hepatitis C, it was significantly higher than that in healthy people and in patients suffering from chronic hepatitis B. There were no significant differences in total sialic acid concentrations in patients with chronic he...Continue Reading

References

Jan 1, 1985·Journal of Cancer Research and Clinical Oncology·N StefenelliP Bauer
Jun 3, 1999·European Journal of Clinical Investigation·P SillanaukeeI P Jääskeläinen
Jul 10, 2004·Zeitschrift Für Naturforschung. C, a Journal of Biosciences·Sanja DabelicGordan Lauc
Jan 23, 2009·Journal of Hepatology·Bram BlommeHans Van Vlierberghe
Jan 6, 2010·Clinical Chemistry and Laboratory Medicine : CCLM·Bogdan CylwikMaciej Szmitkowski
Jun 23, 2012·Medical Principles and Practice : International Journal of the Kuwait University, Health Science Centre·Cristin Constantin VereIon Rogoveanu
Mar 25, 2014·Journal of Clinical Laboratory Analysis·Lech ChrostekMaciej Szmitkowski
Jul 15, 2015·Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases·V SchinzariS Piconese

❮ Previous
Next ❯

Citations


❮ Previous
Next ❯

Methods Mentioned

BETA
glycosylation
sialylation
biopsy
biopsies
Fluorescence
Assay

Related Concepts

Related Feeds

Carcinoma, Lobular

Lobular carcinoma is an invasive type of breast cancer in which lobules, areas of the breast that produce milk, undergo malignant transformation. Here is the latest research.