PMID: 7016213Jan 1, 1981Paper

The concentrations of cephalosporins in tissue fluid of rats with localized infection

Biopharmaceutics & Drug Disposition
I Polacek

Abstract

Rats implanted with multiperforated subcutaneous plastic capsules were used as a model for study of the penetration of four cephalosporins into sites infected with Escherichia coli. The concentrations of the antibiotics were determined in uninfected and infected cages microbiologically up to 4 h after treatment. All four cephalosporins entered infected capsules faster than the control ones and the peak concentrations were attained 30-60 min earlier. The clearance of the antibiotics from infected capsules was faster than from uninfected ones, probably due to inactivation by microbial beta-lactamase(s). Serum protein binding may account for differences in the penetration rate of cephalosporins, but serum level and serum half-time seem to contribute to their kinetic profile in tissue fluid.

References

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