The concept of osseointegration and bone matrix expression
Osseointegration has been defined as the direct structural and functional connection between ordered, living bone and the surface of a load-carrying implant. To date, this concept has been described by descriptive histological and ultrastructural criteria but not by biochemical means. This review evaluates the basic science work performed on this concept and then applies the concept to the principle of osseous healing. Specific studies are cited where alterations in the healing response are due to clinical management of implant placement and how studies of surface properties may lead to further insights on implant design and prognosis. In addition, a review of bone expression as a function of in vitro stress applications is given. This is followed by an indepth review of the collagens and noncollagenous proteins, described to date, within isolated bone matrix. It is this collagenous matrix (especially type I) that is described as being close to and oriented with a glycoprotein component next to the implant surface. In turn, the large family of noncollagenous proteins are important in mediating bone proliferation, matrix accumulation, orientation, mineralization, and turnover. This section is followed by a discussion of specific...Continue Reading
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Timed appearance of a calcium-binding protein containing gamma-carboxyglutamic acid in developing chick bone
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Transforming and nontransforming growth factors are present in medium conditioned by fetal rat calvariae
Cloning and sequence analysis of rat bone sialoprotein (osteopontin) cDNA reveals an Arg-Gly-Asp cell-binding sequence
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Immunocytochemical localization of gamma-carboxyglutamic acid-containing proteins (osteocalcin) in rat bone and dentin
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Unique distribution of the extracellular matrix component thrombospondin in the developing mouse embryo
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Developmental expression of 44-kDa bone phosphoprotein (osteopontin) and bone gamma-carboxyglutamic acid (Gla)-containing protein (osteocalcin) in calcifying tissues of rat
Chemotactic response of mesenchymal cells, fibroblasts and osteoblast-like cells to bone Gla protein
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Wound healing in the bone chamber 1. Neoosteogenesis during transition from the repair to the regenerative phase in the rabbit tibial cortex
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Human platelet-derived transforming growth factor-beta stimulates parameters of bone growth in fetal rat calvariae
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Type beta transforming growth factor (TGF beta) regulation of alkaline phosphatase expression and other phenotype-related mRNAs in osteoblastic rat osteosarcoma cells
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A histological assessment of the initial healing response adjacent to porous-surfaced, titanium alloy dental implants in dogs
Alpha and beta human transforming growth factors stimulate prostaglandin production and bone resorption in cultured mouse calvaria
Mechanical stretching increases the number of cultured bone cells synthesizing DNA and alters their pattern of protein synthesis
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Dissociative extraction and reconstitution of extracellular matrix components involved in local bone differentiation
Effect of titanium surface roughness on chondrocyte proliferation, matrix production, and differentiation depends on the state of cell maturation
Effect of surface roughness and composition on costochondral chondrocytes is dependent on cell maturation state
Anodic oxidation and hydrothermal treatment of titanium results in a surface that causes increased attachment and altered cytoskeletal morphology of rat bone marrow stromal cells in vitro
Periodontal-type measurements associated with hydroxyapatite-coated and non-HA-coated implants: uncovering to 36 months
Structural evolution and adhesion of titanium oxide film containing phosphorus and calcium on titanium by anodic oxidation
Novel production method and in-vitro cell compatibility of porous Ti-6Al-4V alloy disk for hard tissue engineering
The use of osseointegration and rare earth magnetic coupling for oculofacial prosthesis retention in the exenterated orbit
Translucent titanium coating altered the composition of focal adhesions and promoted migration of osteoblast-like MG-63 cells on glass
Surface characteristics and structure of anodic oxide films containing Ca and P on a titanium implant material
In vitro biocompatibility of titanium oxide for prosthetic devices nanostructured by low pressure metal-organic chemical vapor deposition
Quantitative evaluation of the fibrin clot extension on different implant surfaces: an in vitro study
In vivo evaluation of bone-bonding ability of RGD-coated porous implant using layer-by-layer electrostatic self-assembly
Osteoblast response on Ti- and Zr-based bulk metallic glass surfaces after sand blasting modification
Significant role of adhesion properties of primary osteoblast-like cells in early adhesion events for chondroitin sulfate and dermatan sulfate surface molecules
The effect of polymeric chemistry on the expression of bone-related mRNAs and proteins by human bone-derived cells in vitro
Titanium surface topography alters cell shape and modulates bone morphogenetic protein 2 expression in the J774A.1 macrophage cell line
Sandblasted-acid-etched titanium surface influences in vitro the biological behavior of SaOS-2 human osteoblast-like cells
Role of integrin α2 β1 in mediating osteoblastic differentiation on three-dimensional titanium scaffolds with submicron-scale texture
The effect of surface pore size on the differentiation of rat bone marrow cells: morphological observations and expression of bone related protein mRNA
A systematic review of the influence of different titanium surfaces on proliferation, differentiation and protein synthesis of osteoblast-like MG63 cells
Effectiveness of Antibacterial Surfaces in Osseointegration of Titanium Dental Implants: A Systematic Review.
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