The concept of the CCN protein family revisited: a centralized coordination network

Journal of Cell Communication and Signaling
B Perbal

Abstract

The wide array of biological properties attributed to the CCN family of proteins (Perbal in Lancet 363(9402):62-64, 2004) led me to reconsider the possible relationship and roles that these proteins may play as a team, instead of acting on their own as individual regulators in various signaling pathways. The dynamic model which I present in this review stems from the contribution of the biological properties that we established for CCN3, one of the three founding members of the CCN family, which was identified by our group as the first CCN protein showing growth inhibitory properties (1992), expressed mainly in quiescent cells (1996), and showing anti-tumor activities in several cellular models both ex vivo and in vivo. At the present time CCN3 is the only member of the family that has been reported to negatively act on the progression of the cell cycle. The unique dual localisation of CCN3 in the nucleus and outside cells, either at the membrane or in the extracellular matrix, that I first established in 1999, and that now appears to be shared by several other CCN proteins, is a unique essential feature which can no longer be ignored. Based on the structural and functional properties of CCN3, shared by most of the CCN family m...Continue Reading

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Citations

Dec 17, 2018·Acta Physiologica·Andreas ZietzerFelix Jansen
Feb 23, 2020·Scientific Reports·Linling JuZhaolian Bian
Mar 5, 2020·American Journal of Physiology. Cell Physiology·Andrew Leask
Mar 24, 2020·Molecular Human Reproduction·Susanne Elisabeth PorsStine Gry Kristensen
Jul 4, 2020·Disease Models & Mechanisms·Craig M KeenanBlandine Poulet
Sep 21, 2018·Journal of Cell Communication and Signaling·Kunimasa OhtaMasaharu Takigawa
Dec 19, 2019·Journal of Cell Communication and Signaling·Bernard Perbal
Jul 10, 2020·International Journal of Molecular Sciences·Daniel Feng, Casimiro Gerarduzzi
Jul 27, 2020·Journal of Cell Communication and Signaling·Andrew Leask
Nov 6, 2018·Medicines·Norifumi H MoritaniSatoshi Kubota
Jan 12, 2021·Journal of Cell Communication and Signaling·Roos J LeguitRoel Goldschmeding
Jan 30, 2021·Cell and Tissue Research·Andrea E DillingerRudolf Fuchshofer
Mar 4, 2021·Journal of Cellular Physiology·Tomomi MizukawaSatoshi Kubota
Mar 5, 2021·The International Journal of Biochemistry & Cell Biology·Angela Y Y TamDavid J Abraham
Apr 21, 2021·Journal of Cell Communication and Signaling·Herman Yeger, Bernard Perbal
Jun 3, 2021·International Journal of Molecular Sciences·Daniela L RebolledoEnrique Brandan
Jun 15, 2021·Journal of Cell Communication and Signaling·Satoshi KubotaTakashi Nishida
Oct 4, 2021·Fluids and Barriers of the CNS·Vania SepúlvedaTeresa Caprile
Jul 7, 2021·Journal of Cell Communication and Signaling·Veronica Giusti, Katia Scotlandi

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Methods Mentioned

BETA
Circular
Nuclear
Xray diffraction
X-ray
glycosylation

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