Abstract
Alpha1-adrenoceptor antagonists have been shown to decrease both the voiding and storage symptoms of benign prostatic hyperplasia (BPH). Based on the assumption that these symptoms can be attributed to the consequences of the increase in outflow resistance caused by noradrenaline stimulation of stromal alpha1-adrenoceptors in the enlarged prostate, prostatic alpha1-adrenoceptors have become a target for therapeutic interventions. In some patients, alpha1-adrenoceptor antagonists in common clinical use produce intolerable side effects which may be attributed to action on non-prostatic alpha1-adrenoceptors. Therefore, attempts have been made to find alpha1-adrenoceptor antagonists that have selective effects on the prostate ('uroselective' agents), to maintain efficacy in uroflow and eliminate adverse effects. The term uroselectivity has been used in various contexts, but drugs may be discussed as uroselective from a receptor pharmacological, physiological, or clinical perspective. Provided that the alpha1-adrenoceptor subtype in the prostate, bladder neck and urethra is uniform, unique, and cannot be found in other parts of the body, drugs with selectivity for this receptor could be called uroselective. However, available eviden...Continue Reading
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