The concomitant presence of polymorphic alleles of interleukin-1beta, interleukin-6 and apolipoprotein E is associated with an increased risk of myocardial infarction in elderly men. Results from a pilot study

Mechanisms of Ageing and Development
Federico LicastroA Branzi

Abstract

Genetic background of inflammatory or anti-inflammatory molecules may be helpful in identifying subjects with increased or decrease risk of developing cardiovascular disease. Bi-allele polymorphism (C > T) in the promoter region (-511) of the interleukin-1beta (IL-1beta) gene and the bi-allele polymorphism (G > C) in the promoter region (-174) of interleukin-6 (IL-6) gene were determined in elderly men patients with myocardial infarction (MI) and healthy controls. Each subject was also genotyped for the triallelic polymorphism of the apolipoprotein E epsilon gene. The IL-6C and APOE epsilon4 alleles were independently associated with a mild or moderate increased risk of MI, whilst the allele C of the IL-1beta was not independently linked to MI risk. However, the simultaneous presence of the allele C of IL-1beta, the allele C of IL-6 and epsilon4 allele of APOE was strongly associated with the disease. Data from this cross-sectional study suggest that the functional interaction of these three genes affects pathogenetic mechanisms of MI and an impaired regulation of immune responses plays a pivotal role in the disease. Furthermore, genetic background of inflammatory genes may influence longevity of human species by affecting infl...Continue Reading

References

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Citations

Dec 18, 2012·Molecular Biology Reports·Yuan YangRongjing Ding
May 21, 2005·Immunity & Ageing : I & a·Federico LicastroCalogero Caruso
Mar 20, 2012·Clinical Biochemistry·Maria Fernanda Manica-CattaniIvana Beatrice Mânica da Cruz
May 25, 2010·Clinical Biochemistry·Lakhdar GhazouaniTouhami Mahjoub
Jun 25, 2008·Atherosclerosis·Daniel A EnquobahrieDavid S Siscovick
Mar 7, 2006·Mechanisms of Ageing and Development·Fabiola OlivieriClaudio Franceschi
Nov 14, 2008·Coronary Artery Disease·Athanassios ManginasDennis V Cokkinos
Nov 30, 2005·International Journal of Immunogenetics·M ChiappelliF Licastro
Apr 27, 2007·Annals of the New York Academy of Sciences·Maria Paola GrimaldiGiuseppina Candore
Sep 13, 2007·Clinical Chemistry and Laboratory Medicine : CCLM·Peteris TretjakovsValdis Pirags
Mar 20, 2012·Biomarkers : Biochemical Indicators of Exposure, Response, and Susceptibility to Chemicals·Joanna Głogowska-Ligus, Józefa Dąbek
Jul 16, 2015·Inflammation Research : Official Journal of the European Histamine Research Society ... [et Al.]·Haifeng HouZheng Sun
Oct 2, 2021·Inflammation Research : Official Journal of the European Histamine Research Society ... [et Al.]·Himanshu RaiRobert A Byrne

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