The Connection Between Minor H Antigens and Neoantigens and the Missing Link in Their Prediction.

Frontiers in Immunology
T MutisRobbert M Spaapen

Abstract

For hundreds of thousands of years, the human genome has extensively evolved, resulting in genetic variations in almost every gene. Immunological reflections of these genetic variations become clearly visible after an allogeneic stem cell transplantation (allo-SCT) as minor Histocompatibility (H) antigens. Minor H antigens are peptides cleaved from genetically encoded variable protein regions after which they are presented at the cell surface by HLA molecules. After allo-SCT with minor H antigen mismatches between donor and recipient, donor T cells recognize the minor H antigens of the recipient as foreign, evoking strong alloreactive immune responses. Studies in the late eighties have discovered that a subset of minor H antigens are encoded by hematopoietic system-specific genes. After allo-SCT, this subset is strictly expressed on the hematopoietic malignant cells and was therefore the first well-defined highly immunogenic group of tumor-specific antigens. In the last decade, neoantigens derived from genetic mutations in tumors have been identified as another group of immunogenic tumor-specific antigens. Therefore, hematopoietic minor H antigens and neoantigens are therapeutic equivalents. This review will connect our current...Continue Reading

References

Jan 1, 1992·Annals of Oncology : Official Journal of the European Society for Medical Oncology·J C CerottiniT Boon
Jan 20, 1999·The Journal of Experimental Medicine·H DolstraE van de Wiel-van Kemenade
Feb 29, 2000·The Journal of Immunology : Official Journal of the American Association of Immunologists·E H WarrenS R Riddell
Jan 10, 2001·The Journal of Experimental Medicine·A G BricknerS R Riddell
Sep 7, 2001·The Journal of Immunology : Official Journal of the American Association of Immunologists·R A PierceV H Engelhard
Sep 10, 2002·The Journal of Immunology : Official Journal of the American Association of Immunologists·Bregje MommaasTuna Mutis
Oct 2, 2002·European Journal of Immunology·Harry DolstraElly van de Wiel-van Kemenade
Nov 5, 2002·Annual Review of Immunology·Timothy K StarrKristin A Hogquist
May 14, 2003·The Journal of Experimental Medicine·Makoto MurataStanley R Riddell
May 29, 2003·The Journal of Experimental Medicine·Yoshiki AkatsukaToshitada Takahashi
Feb 7, 2004·The Journal of Immunology : Official Journal of the American Association of Immunologists·Helmut W H G KesselsTon N M Schumacher
Apr 23, 2004·Trends in Immunology·Eric SpieringsEls Goulmy
Sep 9, 2006·Science·Edus H WarrenBenoît J Van den Eynde
Nov 2, 2007·BMC Bioinformatics·Mette V LarsenMorten Nielsen
Nov 16, 2007·Cancer Immunology, Immunotherapy : CII·Catherine WölfelThomas Wölfel
Aug 14, 2008·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Scott S TykodiEdus H Warren
Sep 24, 2008·Blood·Michi KameiYoshiki Akatsuka
Apr 4, 2009·The Journal of Immunology : Official Journal of the American Association of Immunologists·Eric SpieringsEls Goulmy
Jul 3, 2009·Bioinformatics·David S DeLucaRainer Blasczyk
Oct 20, 2009·Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation·Henriëtte LevengaReinier Raymakers
Nov 26, 2009·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Robbert M SpaapenTuna Mutis
Nov 30, 2010·Current Opinion in Immunology·Tineke van den HoornJacques Neefjes
Nov 7, 2012·Nature·UNKNOWN 1000 Genomes Project ConsortiumGil A McVean

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Citations

Mar 4, 2021·Cancer Gene Therapy·Mansour PoorebrahimAngel Cid-Arregui
Jul 3, 2021·Transplantation and Cellular Therapy·Sophie Giesler, Robert Zeiser

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Methods Mentioned

BETA
cDNA library
exome sequencing
RNAseq

Clinical Trials Mentioned

NCT03326921
NCT02528682
NCT00943293

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