The consensus on indications, conditioning regimen, and donor selection of allogeneic hematopoietic cell transplantation for hematological diseases in China-recommendations from the Chinese Society of Hematology

Journal of Hematology & Oncology
Lan-Ping XuXiaojun Huang

Abstract

Allogeneic hematopoietic stem cell transplantation (allo-HSCT) is widely used to treat malignant hematological neoplasms and non-malignant hematological disorders. Approximately, 5000 allo-HSCT procedures are performed in China annually. Substantial progress has been made in haploidentical HSCT (HID-HSCT), pre-transplantation risk stratification, and donor selection in allo-HSCT, especially after the establishment of the "Beijing Protocol" HID-HSCT system. Transplant indications for selected subgroups in low-risk leukemia or severe aplastic anemia (SAA) differ from those in the Western world. These unique systems developed by Chinese doctors may inspire the refining of global clinical practice. We reviewed the efficacy of allo-HSCT practice from available Chinese studies on behalf of the HSCT workgroup of the Chinese Society of Hematology, Chinese Medical Association and compared these studies to the consensus or guideline outside China. We summarized the consensus on routine practices of all-HSCT in China and focused on the recommendations of indications, conditioning regimen, and donor selection.

References

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Citations

Aug 23, 2019·Bone Marrow Transplantation·Meng LvXiao-Jun Huang
May 28, 2020·Expert Review of Anticancer Therapy·Yu-Qian SunYing-Jun Chang
Apr 8, 2020·Journal of Hematology & Oncology·Xia LiHe Huang
Aug 25, 2020·Advances in Cell and Gene Therapy·Zheng-Li Xu, Xiao-Jun Huang
Jan 28, 2019·European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology·Jinhua RenTing Yang
Aug 5, 2020·International Journal of Hematology·Lei YeSeiji Kojima
Jul 12, 2020·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Ying-Jun ChangXiao-Jun Huang
Oct 28, 2020·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Lei GaoXi Zhang
Nov 28, 2018·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Meng LvXiao-Jun Huang

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Methods Mentioned

BETA
MDS
flow cytometry

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