The consequences of yield stress on deployment of a non-Newtonian anti-HIV microbicide gel.

Journal of Non-Newtonian Fluid Mechanics
Savas TasogluAndrew J Szeri

Abstract

A recent study in South Africa has confirmed, for the first time, that a vaginal gel formulation of the antiretroviral drug Tenofovir, when applied topically, significantly inhibits sexual HIV transmission to women [10]. However the gel for this drug, and anti-HIV microbicide gels in general, have not been designed using full understanding of how gel spreading and retention in the vagina govern successful drug delivery. Elastohydrodynamic lubrication theory can be applied to model such spreading of microbicide gels, which are inherently non-Newtonian [13,15]. A yield stress is emerging as one of the important properties of microbicide gel vehicle deployment, as this may improve retention within the vaginal canal. On the other hand, a yield stress may decrease the initial extent of the coating flow. Here, we first explain a certain yield stress paradox observed generally in many lubrication flows. Four conditions are determined, via scaling analysis, which mitigate the inconsistency in the use of lubrication theory to analyze the specific problem of elastic wall squeezing flow of yield stress fluid. Parameters characterizing these conditions are obtained experimentally for a test gel. Using them, it is shown that the lubrication...Continue Reading

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Citations

Oct 14, 2014·Journal of Non-Newtonian Fluid Mechanics·Vitaly O Kheyfets, Sarah L Kieweg
Apr 12, 2013·Chemical Society Reviews·Savas TasogluUtkan Demirci
Feb 22, 2013·Journal of Non-Newtonian Fluid Mechanics·Savas TasogluAndrew J Szeri
May 3, 2015·Advanced Drug Delivery Reviews·David F KatzYajing Gao
Jul 29, 2015·Trends in Biotechnology·Stephanie KnowltonSavas Tasoglu
Apr 16, 2015·Drug Delivery and Translational Research·Y GaoD F Katz
Mar 24, 2015·Trends in Biotechnology·Stephanie M KnowltonSavas Tasoglu

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