The conserved molecular machinery in DNA mismatch repair enzyme structures

DNA Repair
Flora S Groothuizen, Titia K Sixma

Abstract

The machinery of DNA mismatch repair enzymes is highly conserved in evolution. The process is initiated by recognition of a DNA mismatch, and validated by ATP and the presence of a processivity clamp or a methylation mark. Several events in MMR promote conformational changes that lead to progression of the repair process. Here we discuss functional conformational changes in the MMR proteins and we compare the enzymes to paralogs in other systems.

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Citations

Dec 29, 2015·DNA Repair·Javier Peña-Diaz, Lene Juel Rasmussen
Jan 5, 2016·DNA Repair·Peter FriedhoffJulia Gotthardt
Jan 8, 2016·DNA Repair·Khek-Chian ThamJoyce H G Lebbink
Dec 22, 2015·DNA Repair·Carol M Manhart, Eric Alani
Jan 1, 2016·DNA Repair·Lyudmila Y Kadyrova, Farid A Kadyrov
May 14, 2016·Nucleic Acids Research·Nicolaas HermansJoyce H G Lebbink
Jul 8, 2017·Genetics·Christopher D Putnam, Richard D Kolodner
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Sep 10, 2020·Environmental Science and Pollution Research International·Saima Shakil MalikRazia Bano
Apr 5, 2017·Frontiers in Microbiology·Fabio CastilloGeorge Szatmari
Dec 22, 2016·Cellular and Molecular Life Sciences : CMLS·Claudia P Spampinato
Aug 6, 2020·Proceedings of the National Academy of Sciences of the United States of America·Christopher D Putnam
Jun 27, 2020·Proceedings of the National Academy of Sciences of the United States of America·Kira C BradfordDorothy A Erie
Oct 6, 2015·Annual Review of Genetics·Thomas A Kunkel, Dorothy A Erie
Jul 6, 2019·International Journal of Clinical Oncology·Kazuo TamuraJunko Tatsumi-Miyajima
Mar 31, 2017·Proceedings of the National Academy of Sciences of the United States of America·Peggy Hsieh, Yongliang Zhang
Sep 5, 2019·International Journal of Molecular Sciences·Yan LiIshita Mukerji
Mar 20, 2021·The Biochemical Journal·Sumedha Dahal, Sathees C Raghavan
Apr 13, 2021·ACS Synthetic Biology·Lorena Fernández-CabezónPablo I Nikel
Jun 6, 2021·Proceedings of the National Academy of Sciences of the United States of America·Jingqi DaiJean-Baptiste Charbonnier
Jul 26, 2019·Bioconjugate Chemistry·Liat KatrivasAlexander Kotlyar

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