The construction of a bioactive peptide database in Metazoa

Journal of Proteome Research
Feng LiuGeert Wets

Abstract

Bioactive peptides play critical roles in regulating most biological processes in animals, and have considerable biological, medical and industrial importance. A number of peptides have been discovered usually based on their biological activities in vitro or based on their sequence similarities in silico. Through searches in Swiss-Prot and Trembl protein databases using BLAST alignment tools and other in silico methods, all currently known bioactive peptides and their precursor proteins are extracted. In addition, 132 recently discovered putative peptide genes in Drosophila as well as their orthologs in other species are collected. In total, 20 027 bioactive peptides from 19 438 precursor proteins covering 2820 metazoan species are retained, and they, respectively, make up a peptide and a peptide precursor database. The peptides and peptide precursor proteins are further classified into 373 families, 178 of which are represented by Prosite Pfam or Smart motifs, or by typical peptide motifs that have been constructed recently. The remaining 195 families are novel peptide families. The motifs characterizing the 178 peptide families are saved into a peptide motif database. The peptide, peptide precursor and peptide motif databases...Continue Reading

References

Mar 15, 1977·Experientia·D H SchlesingerM M Thaler
Sep 1, 1997·Nucleic Acids Research·S F AltschulD J Lipman
May 30, 1998·Proceedings of the National Academy of Sciences of the United States of America·J SchultzC P Ponting
Jun 2, 1998·Nature·S HinumaM Fujino
May 20, 2000·Neuropharmacology·T HökfeltM Diez
Jun 29, 2001·Journal of Gastroenterology·M YonedaA Terano
Sep 12, 2002·Expert Opinion on Therapeutic Targets·Dennis K LeeBrian F O'Dowd
Dec 19, 2003·Nucleic Acids Research·Alex BatemanSean R Eddy
Feb 27, 2004·Protein Engineering, Design & Selection : PEDS·Peter DuckertNikolaj Blom
Feb 25, 2005·Bioinformatics·Dariusz PlewczynskiLeszek Rychlewski
May 14, 2005·Annals of the New York Academy of Sciences·G BaggermanL Schoofs
Nov 18, 2005·Molecular & Cellular Proteomics : MCP·Feng LiuGeert Wets
Dec 31, 2005·Nucleic Acids Research·Nicolas HuloChristian J A Sigrist
Dec 31, 2005·Nucleic Acids Research·Alexander A ZamyatninOlga L Voronina
Feb 28, 2006·Molecular & Cellular Proteomics : MCP·Maria FälthPer E Andren
Oct 20, 2006·Peptides·Feng LiuGeert Wets

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Citations

Jan 24, 2009·Proceedings of the National Academy of Sciences of the United States of America·Marleen LindemansLiliane Schoofs
Apr 10, 2013·Proceedings of the National Academy of Sciences of the United States of America·Markus ConzelmannGáspár Jékely
May 3, 2013·Proceedings of the National Academy of Sciences of the United States of America·Gáspár Jékely
Mar 19, 2013·Bioinformatics·Catherine MooneyDenis C Shields
Sep 26, 2013·Bioinformatics·Thérèse A HoltonCatherine Mooney
May 13, 2009·Nucleic Acids Research·Julien MaupetitPierre Tuffery
Oct 23, 2010·PLoS Biology·James J CollinsPhillip A Newmark
Dec 24, 2013·BMC Genomics·Markus ConzelmannGáspár Jékely
May 27, 2014·General and Comparative Endocrinology·Ravisankar Valsalan, Narayanan Manoj
Feb 2, 2016·Journal of Proteome Research·Rik VerdonckLiliane Schoofs
Jan 10, 2009·Biochemical and Biophysical Research Communications·Marleen LindemansLiliane Schoofs
Jul 2, 2009·Journal of Computational Chemistry·Julien MaupetitPierre Tufféry
Apr 23, 2015·Integrative and Comparative Biology·Nagayasu NakanishiBernard M Degnan
Dec 22, 2014·Biochimica Et Biophysica Acta·Wouter De HaesKurt Boonen
May 2, 2015·Database : the Journal of Biological Databases and Curation·Yan WangTao Xu
Apr 17, 2013·Journal of Proteome Research·David C DallasCarlito B Lebrilla
Mar 14, 2018·International Journal of Food Sciences and Nutrition·Qilin LiMing Chen
Apr 25, 2018·Database : the Journal of Biological Databases and Curation·Jian WangYan Wang
Dec 1, 2019·International Journal of Molecular Sciences·Piotr MinkiewiczMałgorzata Darewicz
Oct 18, 2019·Frontiers in Neuroscience·Auriane CorbièreDavid Vaudry
Dec 7, 2019·BMC Complementary and Alternative Medicine·Stephen R HainesStefan Clerens
May 6, 2017·Scientific Reports·Sherry BhallaGajendra P S Raghava
Sep 17, 2017·Scientific Reports·Youzhong LiuPhilippe Schmitt-Kopplin
Jun 18, 2020·Frontiers in Endocrinology·Elizabeth A Williams
Apr 22, 2018·BMC Bioinformatics·Krittima AnekthanakulMarasri Ruengjitchatchawalya
Jan 1, 2019·Comprehensive Reviews in Food Science and Food Safety·Elena MaestriNelson Marmiroli
Mar 14, 2021·Colloids and Surfaces. B, Biointerfaces·Yuhan YanChunguang Ren
May 18, 2021·Frontiers in Molecular Biosciences·Zahra Sadat HashemiSaeed Khalili
Apr 19, 2018·Journal of the American Society for Mass Spectrometry·Eric B MonroeJonathan V Sweedler

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