The Consumption of Bicarbonate-Rich Mineral Water Improves Glycemic Control

Evidence-based Complementary and Alternative Medicine : ECAM
Shinnosuke MurakamiShinji Fukuda

Abstract

Hot spring water and natural mineral water have been therapeutically used to prevent or improve various diseases. Specifically, consumption of bicarbonate-rich mineral water (BMW) has been reported to prevent or improve type 2 diabetes (T2D) in humans. However, the molecular mechanisms of the beneficial effects behind mineral water consumption remain unclear. To elucidate the molecular level effects of BMW consumption on glycemic control, blood metabolome analysis and fecal microbiome analysis were applied to the BMW consumption test. During the study, 19 healthy volunteers drank 500 mL of commercially available tap water (TW) or BMW daily. TW consumption periods and BMW consumption periods lasted for a week each and this cycle was repeated twice. Biochemical tests indicated that serum glycoalbumin levels, one of the indexes of glycemic controls, decreased significantly after BMW consumption. Metabolome analysis of blood samples revealed that 19 metabolites including glycolysis-related metabolites and 3 amino acids were significantly different between TW and BMW consumption periods. Additionally, microbiome analysis demonstrated that composition of lean-inducible bacteria was increased after BMW consumption. Our results suggest...Continue Reading

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Citations

May 28, 2019·Nutrients·Daniela Costa-VieiraMaria João Martins
Nov 24, 2017·American Journal of Physiology. Renal Physiology·Eikan MishimaTakaaki Abe
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May 1, 2021·International Journal of Molecular Sciences·Nicolas BarnichMonique Alric

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Datasets Mentioned

BETA
DRA004008

Methods Mentioned

BETA
electrophoresis
PCR

Software Mentioned

exactRankTests
house
XLSTAT
QIIME )
R package
in

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