The content of carbon monoxide in the tissues of rats intoxicated with carbon monoxide in various conditions of acute exposure

Archives of Toxicology
J A SokalJ Palus

Abstract

Tissue carbon monoxide (CO) content was investigated in rats severely intoxicated with CO under various exposure conditions: 1% CO for 4 min, 0.4% CO for 40 min and 0.12% CO for 12 h. Extravascular CO was determined in the heart and skeletal muscles immediately after termination of exposure, and carboxymyoglobin (MbCO) percent saturation was calculated. Total brain CO was estimated immediately after termination of exposure and after the time periods of restitution. After the same exposure conditions, MbCO percent saturation was higher in the heart than in skeletal muscle. In both types of muscle, saturation of myoglobin (Mb) with CO depended on blood carboxyhemoglobin (HbCO) level and not on the duration of exposure. The time course of CO elimination was the same for blood and brain, irrespective of CO exposure conditions. The results obtained showed that acute CO intoxication induced by long duration exposures did not involve CO accumulation in the tissues.

References

May 1, 1979·Preventive Medicine·R F Coburn
Jul 4, 1977·Advances in Experimental Medicine and Biology·V Schwarzmann, W A Grunewald
Oct 5, 1970·Annals of the New York Academy of Sciences·B ChanceM Wagner
Apr 1, 1973·The American Journal of Physiology·R F CoburnR Abboud
Jan 1, 1971·The American Journal of Physiology·R F Coburn, L B Mayers
Sep 1, 1965·The Journal of General Physiology·M W CarterC Metzler
Oct 1, 1981·Veterinary Parasitology·P J Waller, R J Thomas

❮ Previous
Next ❯

Citations

Nov 6, 2004·Free Radical Biology & Medicine·Frans J CronjeClaude A Piantadosi
Apr 4, 2013·Expert Review of Respiratory Medicine·Todd F HuzarJames M Cross
Jun 19, 2012·Respiratory Physiology & Neurobiology·C ReboulS Richard
Dec 12, 2003·Birth Defects Research. Part B, Developmental and Reproductive Toxicology·Jarnail Singh
Jun 13, 2006·Birth Defects Research. Part B, Developmental and Reproductive Toxicology·Jarnail Singh
Nov 1, 2013·Sports Medicine·Luisa V Giles, Michael S Koehle
Jan 6, 2015·Journal of Forensic Sciences·Michelangelo Bruno CasaliCristina Cattaneo
May 20, 2003·Journal of Applied Physiology·Eugene N Bruce, Margaret C Bruce

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.