The Continental Divide: Anti-TNF Use in Pediatric IBD Is Different in North America Compared to Other Parts of the World

Canadian Journal of Gastroenterology & Hepatology
Peter C ChurchAnne Griffiths

Abstract

Use of anti-TNF therapies varies internationally. As an initiative of the international Pediatric IBD Network (PIBDNet), we compared global pediatric IBD anti-TNF practice patterns. Physicians were surveyed about anti-TNF use in Crohn's disease (CD) and ulcerative colitis (UC). Chi-squared, independent samples Mann-Whitney U, or related samples Wilcoxon signed rank tests were used to compare groups. 344 physicians treating pediatric IBD responded from 43 countries (54% North America, 29% Europe, 6% Oceania, 6% Asia, 3% Africa, and 2% South America). Respondents treated a median 40 IBD patients. CD was more commonly treated with anti-TNF than UC (40% vs. 10%, p<0.001). North Americans more often used anti-TNF (median 50% vs. 30%, p<0.001) and before immunomodulator (80% vs. 35% CD, p<0.001; 76% vs. 43% steroid-dependent UC, p<0.001). Anti-TNF monotherapy was more common in North America. Anti-TNF in combination with methotrexate, instead of thiopurine, characterized North American practices. North Americans more often continued immunomodulator indefinitely and less often adhered to standard infliximab induction dosing. Access limitations were more common outside North America and Europe for both CD (67% vs. 31%, p<0.001) and UC ...Continue Reading

References

Oct 13, 2001·The New England Journal of Medicine·J KeaneM M Braun
Apr 10, 2007·Digestive Diseases and Sciences·Meaghan DonovanRaymond K Cross
Mar 7, 2009·Inflammatory Bowel Diseases·Meaghan St CharlesRaymond K Cross
Sep 22, 2009·Alimentary Pharmacology & Therapeutics·A OussalahL Peyrin-Biroulet
Apr 16, 2010·The New England Journal of Medicine·Jean Frédéric ColombelUNKNOWN SONIC Study Group
Jun 22, 2010·Inflammatory Bowel Diseases·Eric I BenchimolAnne M Griffiths
Feb 22, 2011·Family Practice·Samuel T CreavinChristian D Mallen
Mar 17, 2011·The American Journal of Gastroenterology·Vincent BillioudLaurent Peyrin-Biroulet
Dec 14, 2011·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·Jeffrey HyamsUNKNOWN T72 Study Group
May 9, 2012·Gastroenterology·Jeffrey S HyamsAndreas Lazar
Jul 10, 2012·Journal of Pediatric Gastroenterology and Nutrition·Dan TurnerUNKNOWN European Society for Paediatric Gastroenterology, Hepatology, and Nutrition
May 29, 2014·Inflammatory Bowel Diseases·Peter C ChurchAnne M Griffiths
Jun 8, 2014·BMC Medical Research Methodology·Sabrina Winona PitSagun Pyakurel
Jun 10, 2014·Journal of Crohn's & Colitis·F M RuemmeleUNKNOWN European Society of Pediatric Gastroenterology, Hepatology and Nutrition
Aug 3, 2014·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·David J GibsonGlen A Doherty
Aug 30, 2014·Digestive and Liver Disease : Official Journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver·Stephan R VavrickaLuc Biedermann
Oct 7, 2014·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·Hans H HerfarthPeter D R Higgins
Mar 19, 2015·Archives of Disease in Childhood·Chani Topf-Olivestone, Dan Turner
Apr 26, 2015·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·Victoria GrossiJeffrey S Hyams
Jul 28, 2016·Expert Opinion on Drug Safety·Tommaso GabbaniVito Annese

❮ Previous
Next ❯

Citations

Jun 11, 2019·Expert Opinion on Drug Metabolism & Toxicology·Raffaella FrancaGabriele Stocco
Jan 22, 2019·Journal of Pediatric Gastroenterology and Nutrition·Jiri BronskyAlmuthe Christina Hauer
Aug 17, 2020·Paediatric Drugs·Karen van Hoeve, Séverine Vermeire
Dec 20, 2019·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Dawn Nolt

❮ Previous
Next ❯

Methods Mentioned

BETA
surgical resection
X-ray

Software Mentioned

REDCap
QuantiFERON
PIBDNet
SPSS Statistics

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.