PMID: 4288294Apr 1, 1966Paper

The continuous estimation of angiotensin formed in the circulation of the dog

The Journal of Physiology
D Regoli, J R Vane

Abstract

1. The use of the rat colon as a blood-bathed organ is described for detecting changes in angiotensin concentration in the circulating blood of dogs.2. Partial occlusion of the aorta by a balloon inflated above the renal arteries leads to a contraction of the blood-bathed rat colon.3. From the experimental evidence, it is concluded that this contraction is due to an increased concentration of circulating angiotensin, brought about by the liberation of renin from the kidneys.4. The characteristics of renin release have been studied. It occurs within seconds of reducing the blood pressure to the kidneys and is proportional to the degree of reduction of blood pressure.5. With a prolonged reduction of renal blood pressure the concentration of angiotensin increases over the first 10-12 min and then reaches a stable level.6. After a small haemorrhage angiotensin often appears in the circulation without a concomitant release of catechol amines.7. Greater haemorrhages induce the secretion of catechol amines as well as of renin. The catechol amine secretion is inhibited by ganglion block, but the renin secretion is not.8. It is concluded that the secretion of renin by the kidneys in response to a fall of renal blood pressure is a physio...Continue Reading

Citations

Aug 1, 1967·British Journal of Pharmacology and Chemotherapy·J Staszewska-Barczak, J R Vane
Sep 27, 2015·Biological Chemistry·Domenico Regoli, Fernand Gobeil
Jun 1, 1975·British Journal of Pharmacology·B N Davies, P G Withrington
Nov 1, 1973·British Journal of Pharmacology·S H FerreiraJ R Vane
Feb 1, 1969·British Journal of Pharmacology·J R Vane
Sep 16, 1967·Nature·S H Ferreira, J R Vane
Oct 28, 1967·Nature·D P Thomas, J R Vane
Apr 13, 1968·Nature·K K Ng, J R Vane
Aug 17, 1968·Nature·R Ginn, J R Vane
Jun 7, 1969·Nature·W P Leary, J G Ledingham
Oct 1, 1970·The British Journal of Surgery·H E Lindsey, J H Wyllie
Sep 1, 1987·Circulation Research·P A MunchA M Brown
Jun 1, 1972·Circulation Research·E H BlaineP D Harris
Oct 15, 1978·Experientia·R J Gryglewski, K C Nicolaou
Jun 23, 1971·Nature: New Biology·S H FerreiraJ R Vane
Oct 23, 2003·Aging Cell·Nicholas R ForsythWoodring E Wright
Jan 9, 1975·The New England Journal of Medicine·E L BravoH P Dustan
Dec 1, 1972·Biochemical Pharmacology·O B Henriques, L Allan

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.