The continuum between neurodegeneration, brain plasticity, and movement: a critical appraisal.

Reviews in the Neurosciences
Tommaso SchirinziLuca Marsili

Abstract

While the "physiological" aging process is associated with declines in motor and cognitive features, these changes do not significantly impair functions and activities of daily living. Differently, motor and cognitive impairment constitute the most common phenotypic expressions of neurodegeneration. Both manifestations frequently coexist in the same disease, thus making difficult to detect "pure" motor or cognitive conditions. Movement disorders are often characterized by cognitive disturbances, and neurodegenerative dementias often exhibit the occurrence of movement disorders. Such a phenotypic overlap suggests approaching these conditions by highlighting the commonalities of entities traditionally considered distinct. In the present review, we critically reappraised the common clinical and pathophysiological aspects of neurodegeneration in both animal models and patients, looking at motricity as a trait d'union over the spectrum of neurodegeneration and focusing on synaptopathy and oscillopathy as the common pathogenic background. Finally, we discussed the possible role of movement as neuroprotective intervention in neurodegenerative conditions, regardless of the etiology. The identification of commonalities is critical to dr...Continue Reading

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Citations

Jul 1, 2020·Journal of Alzheimer's Disease : JAD·Giulia Maria SancesarioTommaso Schirinzi
Oct 8, 2020·Frontiers in Aging Neuroscience·Qianqian ChengZhen Wang
Jun 26, 2021·American Journal of Ophthalmology Case Reports·Techawit LikitgornYaping Joyce Liao
Jul 14, 2021·Expert Review of Neurotherapeutics·Luca MarsiliCarlo Colosimo
Jul 16, 2021·Journal of Neural Transmission·Tommaso SchirinziAntonio Pisani
Jul 29, 2021·Neuropathology and Applied Neurobiology·Megha MurthyConceição Bettencourt

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