Abstract
Prevalence and characteristics of the continuum of diagnoses within fetal alcohol spectrum disorders (FASD) were researched in previously unstudied rural, agricultural, lower socioeconomic populations in South Africa (ZA). Using an active case ascertainment approach among first grade learners, 1354 (72.6%) were consented into the study via: height, weight, and/or head circumference ≤ 25th centile and/or random selection as normal control candidates. Final diagnoses were made following: examination by pediatric dysmorphologists/geneticists, cognitive/behavioral testing, and maternal risk factor interviews. FASD children were significantly growth deficient and dysmorphic: physical measurements, cardinal facial features of FAS, and total dysmorphology scores clearly differentiated diagnostic categories from severe to mild to normal in a consistent, linear fashion. Neurodevelopmental delays were also significantly worse for each of the FASD diagnostic categories, although not as consistently linear across groups. Alcohol use is well documented as the proximal maternal risk factor for each diagnostic group. Significant distal maternal risk factors in this population are: low body weight, body mass, education, and income; and high gr...Continue Reading
References
May 11, 1978·The New England Journal of Medicine·S K Clarren, D W Smith
Nov 3, 1973·Lancet·K L Jones, D W Smith
Feb 1, 1994·American Journal of Public Health·A C King
Feb 6, 1998·Teratology·P D SampsonJ M Graham
Jun 3, 2005·Pediatrics·José F Cordero
Jun 4, 2005·American Journal of Public Health·Philip A MayDenis L Viljoen
Dec 8, 2005·Journal of Studies on Alcohol·Denis L ViljoenPhilip A May
Nov 28, 2006·Drug and Alcohol Dependence·Philip A MayDenis L Viljoen
Feb 2, 2008·IEEE Transactions on Neural Networks·Chengjun Liu, H Wechsler
Mar 14, 2008·Alcoholism, Clinical and Experimental Research·Philip A MayDenis L Viljoen
Sep 5, 2009·Developmental Disabilities Research Reviews·Philip A MayH Eugene Hoyme
Nov 20, 2009·Reproductive Toxicology·Giorgie Petković, Ingeborg Barisić
Jun 11, 2011·Drug and Alcohol Dependence·Philip A MayH Eugene Hoyme
Dec 18, 2012·Alcoholism, Clinical and Experimental Research·Philip A MaySoraya Seedat
Apr 18, 2013·International Journal of Environmental Research and Public Health·Giorgie Petković, Ingeborg Barišić
Jun 4, 2013·South African Medical Journal = Suid-Afrikaanse Tydskrif Vir Geneeskunde·L OlivierD Viljoen
Aug 13, 2013·Drug and Alcohol Dependence·Philip A MaySoraya Seedat
Feb 27, 2014·Reproductive Toxicology·Philip A MayJ Phillip Gossage
Oct 29, 2014·Pediatrics·Philip A MayH Eugene Hoyme
Jan 15, 2015·Pediatrics·Ira J ChasnoffLauren King
Feb 26, 2015·American Journal of Medical Genetics. Part a·H Eugene HoymePhilip A May
May 6, 2015·Alcoholism, Clinical and Experimental Research·Michael F UrbanMatthew F Chersich
Sep 1, 2015·Drug and Alcohol Dependence·Philip A MayH Eugene Hoyme
Oct 2, 2015·Journal of Applied Research in Intellectual Disabilities : JARID·Katarzyna Okulicz-KozarynKrzysztof Brzózka
Citations
May 27, 2016·Alcoholism, Clinical and Experimental Research·Solja NiemeläHeljä-Marja Surcel
Oct 21, 2016·Alcoholism, Clinical and Experimental Research·Onni NiemeläHeljä-Marja Surcel
Oct 30, 2016·Drug and Alcohol Dependence·Philip A MayH Eugene Hoyme
Feb 22, 2017·Addiction·Jürgen RehmPaul A Shuper
May 13, 2017·International Journal of Environmental Research and Public Health·Philip A MayH Eugene Hoyme
Jan 27, 2017·Current Opinion in Psychiatry·Colleen M Adnams
Nov 23, 2017·Metabolic Brain Disease·Oladiran I OlatejuPaul R Manger
Oct 5, 2017·Biochemistry and Cell Biology = Biochimie Et Biologie Cellulaire·S LongstaffeT Brown
Sep 30, 2017·Human Brain Mapping·Dongming ZhouChristian Beaulieu
Oct 4, 2018·Alcohol and Alcoholism : International Journal of the Medical Council on Alcoholism·Moritz Blanck-LubarschAriane Hohoff
Sep 8, 2019·Pediatric Research·Moritz Blanck-LubarschAriane Hohoff
Apr 16, 2020·Alcoholism, Clinical and Experimental Research·Philip A MayH Eugene Hoyme
Apr 16, 2020·Alcoholism, Clinical and Experimental Research·Philip A MayH Eugene Hoyme
Apr 16, 2020·Alcoholism, Clinical and Experimental Research·Philip A MayH Eugene Hoyme
Jul 18, 2020·American Journal of Medical Genetics. Part a·Diego A GomezOmar A Abdul-Rahman
Jun 9, 2018·Wellcome Open Research·Mary BittaCharles R J C Newton
Nov 8, 2018·BMC Public Health·Babatope O AdebiyiAnna-Marie Beytell
Jul 5, 2017·Frontiers in Synaptic Neuroscience·Elissa L WongAnia K Majewska
Feb 14, 2019·CMAJ Open·Deepa SingalLeslie L Roos
Jan 17, 2019·European Child & Adolescent Psychiatry·Cheryl McQuireS Paranjothy
Oct 5, 2019·International Journal of Environmental Research and Public Health·Philip A MayCharles D H Parry
Apr 24, 2020·Frontiers in Human Neuroscience·Kristina A UbanElizabeth R Sowell
Jan 9, 2019·Frontiers in Neurology·Sivenesi SubramoneyKirsten A Donald
Jul 11, 2020·Journal of Autism and Developmental Disorders·Lisa M Whittingham, Kelly D Coons-Harding
Mar 20, 2019·International Journal of Environmental Research and Public Health·Babatope O AdebiyiAnna-Marie Beytell
Dec 1, 2020·Drug and Alcohol Dependence·Philip A MayH Eugene Hoyme
Nov 22, 2020·Journal of Bodywork and Movement Therapies·Keryn MooreYolandi Brink
Aug 4, 2021·Alcoholism, Clinical and Experimental Research·Julie M HaskenPhilip A May
Aug 14, 2021·Drug and Alcohol Dependence·Philip A MayH Eugene Hoyme
Nov 21, 2019·Pediatrics·Wendy O KalbergH Eugene Hoyme
Sep 1, 2016·Pediatrics·Cheryl McQuireAlison Kemp