The continuum of stem cell transdifferentiation: possibility of hematopoietic stem cell plasticity with concurrent CD45 expression

Stem Cells and Development
V M Udani

Abstract

Recent years have seen a surge of scientific research examining adult stem cell plasticity. For example, the hematopoietic stem cell has been shown to give rise to skin, respiratory epithelium, intestinal epithelium, renal epithelium, liver parenchyma, pancreas, skeletal muscle, vascular endothelium, myocardium, and central nervous system (CNS) neurons. The potential for such stem cell plasticity seems to be enhanced by stressors such as injury and neoplasia. Interestingly, recent studies have demonstrated that hematopoietic stem cells may be able to adopt certain nonhematopoietic phenotypes, such as endothelial, neural, or skeletal muscle phenotypes, without entirely losing their initial hematopoietic identity. We propose that transdifferentiation can, in certain conditions, be a partial rather than a complete event, and we encourage further investigation into the phenomenon of a stem cell simultaneously expressing phenotypic features of two distinct cell fates.

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Citations

Jan 27, 2007·Stem Cells and Development·Stan Filip
May 16, 2009·Differentiation; Research in Biological Diversity·Lesley A MathewsW L Farrar
Apr 24, 2007·Progress in Neurobiology·Jessica CarmenMark P Mattson
Mar 6, 2007·Best Practice & Research. Clinical Haematology·David T Scadden
Oct 31, 2006·Hearing Research·Shelley A Batts, Yehoash Raphael
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Jan 1, 2007·Expert Review of Endocrinology & Metabolism·Regina EbertFranz Jakob
Jul 14, 2007·The International Journal of Artificial Organs·L GotloibV Khrizman

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