The contractile response during steady lengthening of stimulated frog muscle fibres

The Journal of Physiology
V Lombardi, G Piazzesi

Abstract

1. Steady lengthenings at different velocities (0.025-1.2 microns/s per half-sarcomere; temperature 2-5.5 degrees C) were imposed on isolated frog muscle fibres at the isometric tetanus plateau by means of a loudspeaker motor. The lengthening at the sarcomere level was measured by means of a striation follower either in fixed-end or in length-clamp mode. The force response was measured by a capacitance gauge transducer (resonance frequency 50 kHz). Preparations showing gross non-homogeneity during lengthening were excluded. 2. A steady tension was in all cases reached after about 20 nm per half-sarcomere of lengthening. Tension during this steady phase rose with speed of elongation up to 0.25-0.4 micron/s per half-sarcomere, when tension was 1.9-2 times isometric tetanic force (T0). Further increase in speed produced only very little increase in the steady tension. 3. During the transitory phase, before steady tension was reached, the tension rose monotonically if speed of lengthening was less than 0.25-0.3 micron/s per half-sarcomere; at higher speed the tension rose above the steady level, reaching a peak when extension was 10-14 nm per half-sarcomere, and then fell to the steady level. Tension at the peak continued to rise w...Continue Reading

Citations

Apr 14, 2010·Proceedings of the National Academy of Sciences of the United States of America·V NucciottiF S Pavone
May 29, 2008·Annals of Biomedical Engineering·D A Smith, S M Mijailovich
Aug 19, 2007·Journal of Comparative Physiology. B, Biochemical, Systemic, and Environmental Physiology·Wendy W H ZhongJoseph F Y Hoh
Jun 27, 2002·Journal of Molecular Biology·Seth C HopkinsYale E Goldman
Nov 19, 2002·Journal of Electromyography and Kinesiology : Official Journal of the International Society of Electrophysiological Kinesiology·Dilson E Rassier, Walter Herzog
Dec 27, 2011·The Journal of Physiology·R ElangovanG Piazzesi
Dec 18, 2013·The Journal of Physiology·Luca FusiVincenzo Lombardi
Dec 31, 1997·The Journal of Physiology·J K ConstableC L Gibbs
Mar 19, 2005·The Journal of Physiology·M Angela BagniBarbara Colombini
Feb 9, 2012·The Journal of Physiology·S Park-HolohanG Piazzesi
Dec 2, 2006·The Journal of Physiology·Julian E StelzerRichard L Moss
Oct 13, 2007·The Journal of Physiology·Barbara ColombiniMaria Angela Bagni
Nov 16, 2002·The Journal of Physiology·Gabriella PiazzesiVincenzo Lombardi
Dec 2, 2009·The Journal of Physiology·Luca FusiGabriella Piazzesi
Nov 14, 2012·Journal of Electromyography and Kinesiology : Official Journal of the International Society of Electrophysiological Kinesiology·Harri PiitulainenJanne Avela
Jan 25, 2011·Journal of Electromyography and Kinesiology : Official Journal of the International Society of Electrophysiological Kinesiology·Romain DenisStéphane Perrey
Sep 15, 2010·Archives of Biochemistry and Biophysics·Enrico Grazi
Jun 15, 2010·Journal of Biomechanics·Stijn van EesbeekErwin de Vlugt
Mar 9, 2010·Journal of Theoretical Biology·Sefi Givli
Oct 20, 2009·Progress in Biophysics and Molecular Biology·C J BarclayN A Curtin
Dec 9, 2008·Journal of Electromyography and Kinesiology : Official Journal of the International Society of Electrophysiological Kinesiology·Michael J FalvoWebb A Smith
Nov 15, 2008·Journal of Molecular and Cellular Cardiology·Mihail I MitovKenneth S Campbell
Jul 25, 2008·Journal of Electromyography and Kinesiology : Official Journal of the International Society of Electrophysiological Kinesiology·Taku WakaharaTetsuo Fukunaga
Jun 14, 2008·Journal of Molecular and Cellular Cardiology·Jorge A Negroni, Elena C Lascano
Mar 18, 2016·Proceedings of the National Academy of Sciences of the United States of America·Marco CaremaniMarco Linari
Oct 27, 2010·Muscle & Nerve·Kathryn A RamseyGavin J Pinniger

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.