The contractile response of thiopental in large and small ovine airways

Acta Anaesthesiologica Scandinavica
S MustafaO Thulesius

Abstract

The present study addresses the question of bronchial reactivity towards thiopental using pharmacological assay and ultrastructural analysis with transmission electron-microscopy in sheep airways. Smooth muscle strips of the upper, middle and lower trachea and small size bronchial rings of sheep were investigated using organ bath technique with monitoring of isometric tension in response to thiopental (10(-7)-10(-4)M), histamine (10(-4)M) and carbachol (10(-8)M). Thiopental elicited contractile responses in the large airways, with most marked contractions in the upper trachea. In the small lobar bronchi thiopental caused a biphasic response with predominant relaxation. Similar reactions could be elicited by histamine. Ultrastructural studies showed a large number of mast cells with equal distribution throughout the bronchial tree. Histamine release from bronchial tissue was detected by bioassay after thiopental challenge. It can be concluded that thiopental at a concentration of 10(-4)M releases histamine from mast cells within the airways with consequent constriction in the trachea and mainly dilatation in the smaller intralobular airways. Under these conditions therefore, one does not necessarily expect a net change of airflo...Continue Reading

References

May 1, 1975·British Journal of Anaesthesia·R S ClarkeJ A Sutton
Sep 1, 1975·Anaesthesia·J WatkinsR S Clarke
Oct 1, 1985·Anesthesiology·C A HirshmanJ M Hanifin
Mar 1, 1985·Journal of Applied Physiology·N A FlavahanP M Vanhoutte
Feb 1, 1971·British Journal of Anaesthesia·M M Clark, H A Cockburn
Jun 1, 1984·Canadian Journal of Physiology and Pharmacology·D F Biggs
Nov 1, 1980·Journal of Applied Physiology: Respiratory, Environmental and Exercise Physiology·T AhmedA Wanner

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Citations

Nov 30, 2002·Paediatric Respiratory Reviews·Siân I Jaggar, Elizabeth Haxby
May 15, 2001·British Journal of Pharmacology·V A SnetkovJ P Ward
Aug 24, 2002·Canadian Journal of Anaesthesia = Journal Canadien D'anesthésie·Giorgio ContiRodolfo Proietti
Jul 16, 2003·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·H MechicheP Devillier

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