PMID: 8963034Sep 1, 1995Paper

The contrasting influence of chronic nicotine intake on gastrin and gastric acid secretion

Journal of Gastroenterology and Hepatology
D Wong, C W Ogle

Abstract

The effects of chronic nicotine treatment on gastric acid secretion stimulated by subcutaneous injection of pentagastrin, as well as on serum gastrin levels and the stomach parietal cell population, were examined. Rats drank a solution of nicotine 25 micrograms/mL tap water for periods of 10, 30 or 45 days. Pentagastrin increased the gastric secretory volume and acid output in pylorus-ligated control animals that drank tap water. Animals given nicotine in their drinking water for 10, 30 or 45 days showed increased basal gastric secretion and acid output. Pentagastrin produced maximum stimulatory effects at lower dose levels of 50 micrograms/kg in the 10-day treatment group and 25 micrograms/kg in the 30- or 45-day treatment groups; however, the maximum responses to pentagastrin in all nicotine-treated batches were comparable to those of their corresponding controls. Serum gastrin levels remained unchanged from the 10th day of nicotine treatment, whereas the levels in the control animals continued to rise with age. Nicotine 25 micrograms/mL drinking water given for 10, 30 or 45 days caused no significant changes in the parietal cell population, mucosal surface area or mucosal thickness. These findings are consistent with the ide...Continue Reading

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Citations

Sep 20, 2012·Nicotine & Tobacco Research : Official Journal of the Society for Research on Nicotine and Tobacco·Michele Zoli, Marina R Picciotto
May 26, 2010·Neurochemical Research·A Lajtha, H Sershen
Jun 17, 2015·Experimental Physiology·Soad Shaker AliMansour Ibrahem Suliman
Nov 19, 2002·Journal of Neurobiology·Mariella De Biasi
Aug 27, 2014·Scandinavian Journal of Gastroenterology·Liping SunYuan Yuan

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