The contribution of αβ-tubulin curvature to microtubule dynamics

The Journal of Cell Biology
Gary J Brouhard, Luke M Rice

Abstract

Microtubules are dynamic polymers of αβ-tubulin that form diverse cellular structures, such as the mitotic spindle for cell division, the backbone of neurons, and axonemes. To control the architecture of microtubule networks, microtubule-associated proteins (MAPs) and motor proteins regulate microtubule growth, shrinkage, and the transitions between these states. Recent evidence shows that many MAPs exert their effects by selectively binding to distinct conformations of polymerized or unpolymerized αβ-tubulin. The ability of αβ-tubulin to adopt distinct conformations contributes to the intrinsic polymerization dynamics of microtubules. αβ-Tubulin conformation is a fundamental property that MAPs monitor and control to build proper microtubule networks.

References

Dec 1, 1992·The Journal of Cell Biology·H AizawaN Hirokawa
Sep 1, 1991·The Journal of Cell Biology·E M MandelkowRonald A Milligan
Apr 1, 1974·Proceedings of the National Academy of Sciences of the United States of America·M KirschnerJ C Gerhart
Nov 15, 1984·Nature·T J Mitchison, M Kirschner
Jun 1, 1995·The Journal of Cell Biology·Denis ChrétienEric Karsenti
Sep 1, 1995·Biophysical Journal·David J OddeH M Buettner
Jan 15, 1998·Nature·Eva NogalesKenneth H Downing
Jun 9, 1998·Human Molecular Genetics·V des PortesC Beldjord
Aug 12, 1998·The Journal of Cell Biology·T ManeyLinda Wordeman
Feb 16, 1999·Cell·Arshad DesaiClaire E Walczak
Feb 17, 2000·The EMBO Journal·Michel O SteinmetzJ van Oostrum
Aug 18, 2000·The Journal of Biological Chemistry·K R TaylorJ G Gleeson
Oct 9, 2001·Mechanisms of Ageing and Development·M Sjögren, A Wallin
Oct 30, 2001·International Journal of Medical Microbiology : IJMM·M Aepfelbacher, J Heesemann
May 2, 2002·Molecular Cell·Carolyn A MooresRonald A Milligan
Apr 15, 2003·Nature Structural Biology·Myung Hee KimZygmunt S Derewenda
Jun 25, 2003·The Journal of Cell Biology·Marcel E JansonMarileen Dogterom
Jul 15, 2003·The Journal of Biological Chemistry·Ikuko Hayashi, Mitsuhiko Ikura
Jul 16, 2003·The Journal of Biological Chemistry·Srinivas HonnappaMichel O Steinmetz
Nov 26, 2003·Cell·Atsuko KodamaElaine Fuchs
Mar 19, 2004·The EMBO Journal·Krista ShipleyRobert Fletterick
Mar 20, 2004·Science·Philipp NiethammerEric Karsenti
Jun 18, 2004·Molecular Cell·Carolyn A MooresRonald A Milligan
May 27, 2005·Nature·Benoît GigantMarcel Knossow
Jun 14, 2005·Biophysical Journal·Vincent VanBurenDavid J Odde
Oct 26, 2005·Current Biology : CB·Neil J GanemDuane A Compton
Nov 24, 2005·Current Biology : CB·Gohta GoshimaRonald D Vale
Mar 29, 2006·The Journal of Cell Biology·Jawdat Al-BassamAnthony A Hyman
Jul 27, 2006·Genes to Cells : Devoted to Molecular & Cellular Mechanisms·Yuko Mimori-KiyosueIvan Vorobjev
Aug 15, 2006·Nature Cell Biology·Vladimír VargaJonathon Howard
Sep 5, 2006·Molecular Cell·Srinivas HonnappaMichel O Steinmetz
Dec 23, 2006·Current Opinion in Cell Biology·Jonathon Howard, Anthony A Hyman
Sep 25, 2007·Molecular Cell·Kevin C Slep, Ronald D Vale
Dec 7, 2007·Nature·Peter BielingThomas Surrey
Dec 7, 2007·Developmental Cell·Scott V Bratman, Fred Chang
Jan 15, 2008·Cell·Gary J BrouhardAnthony A Hyman
Feb 6, 2008·Current Biology : CB·Ilya GrigorievAnna Akhmanova
Mar 7, 2008·Nature Reviews. Molecular Cell Biology·Anna Akhmanova, Michel O Steinmetz
Mar 28, 2008·Nature Cell Biology·Benjamin VitreIsabelle Arnal
Apr 5, 2008·Proceedings of the National Academy of Sciences of the United States of America·Luke M RiceDavid A Agard
Sep 12, 2008·Nature Reviews. Molecular Cell Biology·Michael Overholtzer, Joan S Brugge
Sep 17, 2008·The Journal of Cell Biology·Elizabeth M Wilson-KubalekRonald A Milligan
Sep 17, 2008·Nature Structural & Molecular Biology·Amédée des GeorgesLinda A Amos
Jul 28, 2009·Cell·Srinivas HonnappaMichel O Steinmetz
Oct 24, 2009·PloS One·Marija ZanicJonathon Howard
Dec 8, 2009·Nature Structural & Molecular Biology·Jeremy R CooperLinda Wordeman
Feb 16, 2010·Current Biology : CB·Yaqing DuRyoma Ohi
Feb 18, 2010·Proceedings of the National Academy of Sciences of the United States of America·Charles V Sindelar, Kenneth H Downing
May 15, 2010·Methods in Cell Biology·Christopher GellJonathon Howard
Aug 3, 2010·The Journal of Biological Chemistry·Pascale BarbierJosé M Andreu
Aug 17, 2010·Developmental Cell·Jawdat Al-BassamFred Chang
Sep 8, 2010·The EMBO Journal·Carsten PetersCarolyn A Moores
Oct 15, 2010·Nature·Gregory M AlushinEva Nogales
Oct 27, 2010·The Journal of Cell Biology·Franck J FourniolCarolyn A Moores
Feb 2, 2011·Proceedings of the National Academy of Sciences of the United States of America·Per O WidlundJonathon Howard
Mar 4, 2011·Proceedings of the National Academy of Sciences of the United States of America·Sebastian P MaurerThomas Surrey
Jul 27, 2011·Journal of Molecular Biology·Agata NawrotekBenoît Gigant
Aug 23, 2011·Cell·Melissa K GardnerDavid J Odde
Mar 21, 2012·Proceedings of the National Academy of Sciences of the United States of America·Cécile LeducJonathon Howard
Jun 15, 2012·Molecular Biology of the Cell·Jawdat Al-BassamFred Chang
Jun 26, 2012·Developmental Cell·Susanne Bechstedt, Gary J Brouhard
Jul 11, 2012·Proceedings of the National Academy of Sciences of the United States of America·Ludovic PecqueurMarcel Knossow
Aug 22, 2012·Proceedings of the National Academy of Sciences of the United States of America·Neil T UmbreitTrisha N Davis
Sep 21, 2012·Molecular Biology of the Cell·Per O WidlundDavid N Drechsel
Jan 5, 2013·Science·Andrea E ProtaMichel O Steinmetz
Mar 28, 2013·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·Hugo Bowne-AndersonJonathon Howard
May 15, 2013·Nature Cell Biology·Marija ZanicJonathon Howard
Jul 9, 2013·Current Biology : CB·Courtney CoombesMelissa K Gardner
Jul 23, 2013·Cell·Radhika SubramanianTarun M Kapoor
Jul 23, 2013·Nature Structural & Molecular Biology·Benoît GigantMarcel Knossow
Nov 29, 2013·Proceedings of the National Academy of Sciences of the United States of America·Kamlesh K GuptaHolly V Goodson
Feb 11, 2014·Current Biology : CB·Sebastian P MaurerThomas Surrey
Mar 13, 2014·The Journal of Cell Biology·Rania S RizkMohan L Gupta
Oct 7, 2014·Current Biology : CB·Susanne BechstedtGary J Brouhard

Citations

Feb 13, 2016·Scientific Reports·Frauke HussmannRobert A Cross
Jan 25, 2016·Current Opinion in Structural Biology·Eva Nogales, Rui Zhang
Dec 20, 2015·Biophysical Journal·Pavel ZakharovEkaterina L Grishchuk
Dec 5, 2015·Frontiers in Psychiatry·Valeria Hansberg-PastorIgnacio Camacho-Arroyo
Nov 13, 2015·Nature Reviews. Molecular Cell Biology·Anna Akhmanova, Michel O Steinmetz
May 15, 2015·Protein Science : a Publication of the Protein Society·Dan E McNamaraJorge Z Torres
Aug 8, 2015·Neuron·Lukas C Kapitein, Casper C Hoogenraad
Apr 29, 2015·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·Qin WangYaping Wang
Apr 19, 2015·Current Opinion in Endocrinology, Diabetes, and Obesity·Nan LiC Yan Cheng
May 6, 2016·Annual Review of Biochemistry·Sabine Petry
Jun 28, 2016·Journal of Medicinal Chemistry·María-Jesús Pérez-PérezSandra Liekens
Aug 7, 2016·Brain Research Bulletin·Almudena Pacheco, Gianluca Gallo
Aug 18, 2016·Brain Research Bulletin·André VoelzmannAndreas Prokop
Oct 8, 2016·Cell Adhesion & Migration·Mathijs VleugelMarileen Dogterom
Nov 10, 2016·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Souvik BanerjeeDuane D Miller
Nov 5, 2016·Chemphyschem : a European Journal of Chemical Physics and Physical Chemistry·Paul Hendrik SchummelRoland Winter
Dec 22, 2016·The Journal of Physical Chemistry. B·Sarmistha Majumdar, Shubhra Ghosh Dastidar
Mar 31, 2017·Scientific Reports·Lurlène AkendengueAnne Marie Wehenkel
Apr 25, 2017·Nature Cell Biology·Kai JiangAnna Akhmanova
Apr 5, 2017·Scientific Reports·J S AparnaDibyendu Das
Mar 24, 2017·Molecular Biology and Evolution·Anders K KrabberødKamran Shalchian-Tabrizi
Apr 16, 2016·Clinical Medicine Insights. Oncology·Gerald M Higa, Corbin Sypult
Mar 16, 2017·ELife·Wilhelmina E van RielAnna Akhmanova
Jun 22, 2017·Endocrine-related Cancer·Rachana Rao Battaje, Dulal Panda
Sep 22, 2018·Physical Chemistry Chemical Physics : PCCP·Paul Hendrik SchummelRoland Winter
Aug 7, 2018·Human Mutation·Franca VulinovicAleksandar Rakovic
Feb 13, 2019·Medicinal Research Reviews·Kinsie E ArnstDuane D Miller
Mar 5, 2019·Chemphyschem : a European Journal of Chemical Physics and Physical Chemistry·Paul Hendrik SchummelRoland Winter
Nov 1, 2018·The Journal of Cell Biology·Jelmer J LindeboomDavid W Ehrhardt
Aug 24, 2017·Nature Reviews. Molecular Cell Biology·Johanna Roostalu, Thomas Surrey
Jun 21, 2019·Journal of Thrombosis and Haemostasis : JTH·Dorsaf GhalloussiWolfgang Bergmeier
Jun 9, 2019·Journal of Cell Science·Anna Akhmanova, Michel O Steinmetz
Mar 5, 2016·The Journal of Biological Chemistry·Felipe Montecinos-FranjolaDan L Sackett
Jun 19, 2019·Current Topics in Medicinal Chemistry·Yongtao DuanChuanjun Song
Feb 21, 2020·Protein Science : a Publication of the Protein Society·Xuecheng YeLuke M Rice
Jan 19, 2019·Life Science Alliance·Heidi Lh MalabyJason Stumpff
Jan 14, 2016·Oncotarget·Claudia CompagnucciEnrico Bertini
Sep 5, 2020·The Journal of Cell Biology·Shubham KesarwaniMinhajuddin Sirajuddin
May 10, 2015·The Journal of Biological Chemistry·Ray Alfaro-Aco, Sabine Petry
Apr 7, 2016·ELife·Christian DuellbergThomas Surrey
Nov 2, 2017·Journal of Biological Physics·Vlado A BuljanRichard B Banati
Oct 3, 2018·Proceedings of the National Academy of Sciences of the United States of America·Shishen DuJoe Lutkenhaus
Apr 21, 2018·Nature Reviews. Molecular Cell Biology·Gary J Brouhard, Luke M Rice
Apr 4, 2019·Molecular Biology of the Cell·Tae Kim, Luke M Rice
Oct 9, 2019·The Journal of Chemical Physics·Cheng-Tai Lee, Eugene M Terentjev
May 26, 2018·The Journal of Cell Biology·J Richard McIntoshNikita Gudimchuk
Jun 20, 2018·Proceedings of the National Academy of Sciences of the United States of America·Rui ZhangEva Nogales
Jun 7, 2018·Acta Crystallographica. Section D, Structural Biology·Joseph AthertonCarolyn A Moores
Jul 4, 2019·The Journal of Biological Chemistry·Rebecca L BestStuart C Feinstein
May 18, 2017·The Journal of Cell Biology·Amy E Byrnes, Kevin C Slep
Feb 26, 2019·Proceedings of the National Academy of Sciences of the United States of America·Keith J MickolajczykWilliam O Hancock

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Microtubule-Associated Protein 3
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