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The contribution of alpha 1-acid glycoprotein, lipoproteins, and albumin to the plasma binding of perazine, amitriptyline, and nortriptyline in healthy man

Naunyn-Schmiedeberg's Archives of Pharmacology

Oct 1, 1980

M Brinkschulte, U Breyer-Pfaff

PMID: 6108517

Abstract

Parameters for the binding of perazine (PER), amitriptyline (AT) and nortriptyline (NT) to plasma and to single plasma proteins were determined by equilibrium dialysis. The highest affinity (K at least 10(5) M-1) and lowest capacity (first site 1 mol/mol) towards all three drugs was exh...read more

Mentioned in this Paper

Antipsychotic Effect
Perazine Maleate (1: 2)
Orosomucoid
ALB
Nortriptyline Assay
Plasma Protein Binding Capacity
Plasma Proteins
Amitriptyline Hydrochloride
Plasma Albumin
Lipoproteins
Paper Details
References
  • References16
  • Citations26
12
  • References16
  • Citations26
123

The contribution of alpha 1-acid glycoprotein, lipoproteins, and albumin to the plasma binding of perazine, amitriptyline, and nortriptyline in healthy man

Naunyn-Schmiedeberg's Archives of Pharmacology

Oct 1, 1980

M Brinkschulte, U Breyer-Pfaff

PMID: 6108517

DOI:

Abstract

Parameters for the binding of perazine (PER), amitriptyline (AT) and nortriptyline (NT) to plasma and to single plasma proteins were determined by equilibrium dialysis. The highest affinity (K at least 10(5) M-1) and lowest capacity (first site 1 mol/mol) towards all three drugs was exh...read more

Mentioned in this Paper

Antipsychotic Effect
Perazine Maleate (1: 2)
Orosomucoid
ALB
Nortriptyline Assay
Plasma Protein Binding Capacity
Plasma Proteins
Amitriptyline Hydrochloride
Plasma Albumin
Lipoproteins
Paper Details
References
  • References16
  • Citations26
12
  • References16
  • Citations26
123
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