The Contribution of Autoantibodies to Inflammatory Cardiovascular Pathology

Frontiers in Immunology
Lee A Meier, Bryce A Binstadt

Abstract

Chronic inflammation and resulting tissue damage underlie the vast majority of acquired cardiovascular disease (CVD), a general term encompassing a widely diverse array of conditions. Both innate and adaptive immune mechanisms contribute to chronic inflammation in CVD. Although maladies, such as atherosclerosis and cardiac fibrosis, are commonly conceptualized as disorders of inflammation, the cellular and molecular mechanisms that promote inflammation during the natural history of these diseases in human patients are not fully defined. Autoantibodies (AAbs) with specificity to self-derived epitopes accompany many forms of CVD in humans. Both adaptive/induced iAAbs (generated following cognate antigen encounter) and also autoantigen-reactive natural antibodies (produced independently of infection and in the absence of T cell help) have been demonstrated to modulate the natural history of multiple forms of CVD including atherosclerosis (atherosclerotic cardiovascular disease), dilated cardiomyopathy, and valvular heart disease. Despite the breadth of experimental evidence for the role of AAbs in CVD, there is a lack of consensus regarding their specific functions, primarily due to disparate conclusions reached, even when similar...Continue Reading

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Citations

Sep 19, 2019·Stroke; a Journal of Cerebral Circulation·Pia S SperberThomas G Liman
Sep 1, 2019·Current Pharmaceutical Design·Nathalie SattaSabrina Pagano
Aug 14, 2020·Immunity, Inflammation and Disease·Kseniya FominaAnna Gorbushina
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Jul 30, 2021·Clinical and Translational Medicine·Laura Lopez-SanzCarmen Gomez-Guerrero
Aug 28, 2021·International Journal of Molecular Sciences·Anastasia V PoznyakAlexander N Orekhov

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Methods Mentioned

BETA
gene knockout
transgenic
dissection

Software Mentioned

CANTOS

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