PMID: 12755808May 21, 2003Paper

The contribution of clinical pharmacology to antimalarial drug discovery and development

British Journal of Clinical Pharmacology
Peter Winstanley

Abstract

Unlike human immunodeficiency virus (HIV) disease or tuberculosis, both of which are also major threats to public health throughout the tropics, uncomplicated falciparum malaria is relatively cheaply and rapidly cured, usually in Outpatients. However, in common with both HIV and TB (but to varying degrees), control of malaria is threatened by inadequate resources and drug resistance. Worldwide, it is Africa that carries the greatest burden of falciparum malaria mortality and morbidity; by no coincidence, it is also Africa that is most resource-limited. The drugs for severe disease (quinine and the artemisinins) are largely unaffected by resistance so far, but the 'first-line' drugs, mostly used by outpatients (mainly chloroquine and sulfadoxine-pyrimethamine) are a major cause for concern. Although effective drugs are available, they are largely too expensive for routine use. The present article reviews the ways in which clinical pharmacology has contributed to the identification of new drugs and strategies for malaria.

References

Nov 1, 1995·Transactions of the Royal Society of Tropical Medicine and Hygiene·M B van HensbroekB M Greenwood
Aug 27, 1998·Pharmacology & Therapeutics·M Foley, L Tilley
Oct 14, 1998·Comptes rendus de l'Académie des sciences. Série III, Sciences de la vie·J F TrapeF Simondon
May 5, 2000·The Cochrane Database of Systematic Reviews·P Olliaro, P Mussano
Feb 13, 2001·The Journal of Nutrition·B J BrabinD Pelletier

❮ Previous
Next ❯

Citations

Dec 25, 2004·European Journal of Clinical Pharmacology·Jens RengelshausenIngeborg Walter-Sack
May 21, 2003·British Journal of Clinical Pharmacology·Kevin Marsh
Mar 17, 2015·Asian Pacific Journal of Cancer Prevention : APJCP·Suyanee ThongchotNisana Namwat
Aug 7, 2012·British Journal of Clinical Pharmacology

❮ Previous
Next ❯

Related Concepts

Related Feeds

Antimalarial Agents (ASM)

Antimalarial agents, also known as antimalarials, are designed to prevent or cure malaria. Discover the latest research on antimalarial agents here.

Antimalarial Agents

Antimalarial agents, also known as antimalarials, are designed to prevent or cure malaria. Discover the latest research on antimalarial agents here.