The contribution of CYP2C gene subfamily involved in epoxygenase pathway of arachidonic acids metabolism to hypertension susceptibility in Russian population

Clinical and Experimental Hypertension : CHE
Alexey PolonikovVladimir Ivanov

Abstract

Numerous studies demonstrated an importance of cytochrome P-450 epoxygenase pathway of arachidonic acids metabolism for the pathogenesis of essential hypertension (EH). The present study was designed to investigate whether common single-nucleotide polymorphisms (SNP) of CYP2C gene subfamily such as CYP2C8 (rs7909236 and rs1934953), CYP2C9 (rs9332242), and CYP2C19 (rs4244285) are associated with susceptibility to EH in Russian population. A total of 816 unrelated Russian individuals comprising 425 EH patients and 391 normotensive controls were included into the study. Genotyping of SNPs was performed using the MassARRAY 4 system. SNP rs7909236 of CYP2C8 was significantly associated with increased risk of EH (OR adjusted for sex and age was 2.99 95% CI 1.39-6.44, P = 0.005). SNPs rs1934953 CYP2C8 and rs4244285 of CYP2C19 showed association with EH risk but at a borderline statistical significance (P ≤ 0.04). Combination of genotypes CYP2C8 rs7909236 TT and CYP2C19 rs4244285 GG was associated with increased EH risk (OR 3.34 95%CI 1.48-7.51, P = 0.004). Genotype-phenotype correlation analysis showed that the levels of CYP2C8 mRNA were significantly correlated with SNP rs7909236 (P = 0.01). in silico functional prediction analysis r...Continue Reading

References

Jan 1, 1991·Annual Review of Pharmacology and Toxicology·J C McGiff
May 3, 2005·Pharmacogenetics and Genomics·Lorraine M KingDarryl C Zeldin
Oct 6, 2005·American Journal of Hypertension·Albert W DreisbachJuan J L Lertora
Feb 3, 2007·Bioinformatics·Juan R GonzálezVíctor Moreno
Feb 9, 2007·Annals of Human Genetics·Sheng-Nan WuDing-Liang Zhu
Oct 10, 2007·The Pharmacogenomics Journal·C Rodríguez-AntonaM Ingelman-Sundberg
Nov 6, 2007·Pharmacogenomics·Katherine N Theken, Craig R Lee
Jan 23, 2010·Pharmacology & Therapeutics·Beshay N M Zordoky, Ayman O S El-Kadi
May 25, 2010·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Craig R LeeDarryl C Zeldin
Sep 13, 2011·Nature·UNKNOWN International Consortium for Blood Pressure Genome-Wide Association StudiesToby Johnson
Jun 27, 2012·Genetic Testing and Molecular Biomarkers·Abdullah AlghashamAhmad A Settin
Sep 27, 2012·Journal of Cardiovascular Pharmacology·Jeremy Bellien, Robinson Joannides
Oct 18, 2012·Yonsei Medical Journal·Dong-Jik ShinYangsoo Jang
Jan 11, 2013·Current Opinion in Nephrology and Hypertension·Jorge Capdevila, Wenhui Wang
Jan 11, 2013·European Heart Journal·Georg B Ehret, Mark J Caulfield
Aug 6, 2014·Biochimica Et Biophysica Acta·Arthur A Spector, Hee-Yong Kim
Jan 15, 2015·Hypertension·John D Imig
Mar 15, 2015·Circulation Research·Sandosh PadmanabhanAnna F Dominiczak
Mar 31, 2016·Clinical and Experimental Hypertension : CHE·M SinghI S Gambhir

❮ Previous
Next ❯

Citations

Aug 2, 2019·Pharmacogenomics·Karin B MirzaevDmitry A Sychev
Apr 3, 2020·Xenobiotica; the Fate of Foreign Compounds in Biological Systems·Hui HeChao Yu
Aug 23, 2019·International Journal of Molecular Sciences·George Anderson, Gianluigi Mazzoccoli

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.