The Contribution of Different Components in QiShenYiQi Pills® to Its Potential to Modulate Energy Metabolism in Protection of Ischemic Myocardial Injury

Frontiers in Physiology
Yuan-Chen CuiJing-Yan Han

Abstract

Ischemic heart diseases remain a challenge for clinicians. QiShenYiQi pills® (QSYQ) has been reported to be curative during coronary heart diseases with modulation of energy metabolism as one of the underlying mechanisms. In this study, we detected the effect of QSYQ and its components on rat myocardial structure, mitochondrial respiratory chain complexes activity and energy metabolism, and heart function after 30 min of cardiac ischemia, with focusing on the contribution of each component to its potential to regulate energy metabolism. Results showed that treatment with QSYQ and all its five components protected myocardial structure from damage by ischemia. QSYQ also attenuated release of myocardial cTnI, and restored the production of ATP after cardiac ischemia. AS-IV and Rb1, but not Rg1, R1, and DLA, had similar effect as QSYQ in regulation of energy metabolism. These results indicate that QSYQ may prevent ischemia-induced cardiac injury via regulation of energy metabolism, to which each of its components contributes differently.

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Citations

Apr 20, 2019·Evidence-based Complementary and Alternative Medicine : ECAM·Huiyang ChenAiming Wu
May 31, 2019·Chinese Journal of Integrative Medicine·Hui MengPeng-Fei Tu
Dec 8, 2020·Evidence-based Complementary and Alternative Medicine : ECAM·Miaomiao LiuLi Chu
Jun 29, 2021·Frontiers in Physiology·Jing-Yan HanQiao-Bing Huang
Jul 29, 2021·Phytomedicine : International Journal of Phytotherapy and Phytopharmacology·Yuting HuangGuanwei Fan

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Methods Mentioned

BETA
protein assay
electrophoresis
ELISA

Software Mentioned

QSYQ
Pro plus
GraphPad
Image
GraphPad Prism

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