PMID: 1205024Dec 1, 1975Paper

The contribution of endogenous insulin secretion to the ketogenic response to glucagon in man

Diabetologia
D S Schade, R P Eaton

Abstract

The magnitude and direction of the lipolytic and ketogenic responses following exogenous glucagon administration is controversial and consideration of the possible role of endogenous insulin secretion upon these events has not been clarified. The present study examines the role of endogenous insulin secretion in modulating the net lipolytic and ketogenic activity of glucagon. Three groups characterized by different levels of endogenous insulin secretory capacity were studied. In all three groups, the responses in plasma insulin, betahydroxybutyrate, and free fatty acids were observed following bolus administration of 1.0 mug/kg glucagon. In the obese subjects with increased endogenous insulin secretion, glucagon administration resulted in a decline below basal levels of both free fatty acid and betahydroxybutyrate. In the diabetic subjects with no demonstrable endogenous insulin secretion, glucagon administration was followed by a rise in plasma free fatty acids and an exaggerated rise in plasma betahydroxybutyrate. The normal control group exhibited a response in betahydroxybutyrate midway between the obese and diabetic groups. These obwervations support the thesis that the magnitude of endogenous insulin secretion modulates t...Continue Reading

References

May 8, 1975·The New England Journal of Medicine·J E GerichP H Forsham
Mar 1, 1975·The Journal of Clinical Endocrinology and Metabolism·J E GerichD M Bier
Apr 1, 1975·The Journal of Clinical Endocrinology and Metabolism·D S Schade, R P Eaton
Nov 1, 1968·British Journal of Pharmacology·G P Lewis, J Matthews
Sep 1, 1974·Diabetes·R ParrillaC J Toews
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Citations

Sep 1, 1978·Acta diabetologica latina·R NosadiniA Tiengo
Sep 1, 1977·Clinical Endocrinology·R W SimpsonK G Albert
Apr 1, 1982·Metabolism: Clinical and Experimental·A GillK G Alberti
Aug 1, 1979·Metabolism: Clinical and Experimental·D S SchadeR P Eaton
Jun 1, 1991·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·C VonsD Franco
Sep 1, 1983·Acta Pharmacologica Et Toxicologica·J Buch, A Buch

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