The contribution of feedback loops between miRNAs, cytokines and growth factors to the pathogenesis of psoriasis

Experimental Dermatology
Moamen MasalhaDror Avni

Abstract

The present review describes in detail the existent data regarding feedback loops between miRNAs and cytokines or growth factors in the psoriatic inflammation. We have chosen to describe the roles of miR-31, miR-21, miR-146a, miR-155, miR-197 and miR-99a in this process. This choice derives from the fact that among around 250 miRNAs being altered in the psoriatic lesion, the comprehensive functional role was described only in those detailed above. In addition, considering the molecular targets and the pathways, which may possibly be regulated by those miRNAs, it seems that they may be chosen as preferred targets for the therapy of psoriasis.

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Citations

Nov 8, 2018·Biomedical Reports·Teodora Larisa Timis, Remus Ioan Orasan
Aug 12, 2020·Experimental Dermatology·Moamen MasalhaDror Avni
May 16, 2020·Journal of Immunology Research·Shiju XiaoGuangzhong Zhang
Oct 21, 2020·European Journal of Immunology·Katrien Van RaemdonckShiva Shahrara
Mar 16, 2021·Frontiers in Medicine·Yang Xiuli, Wang Honglin
Aug 12, 2021·Translational Research : the Journal of Laboratory and Clinical Medicine·Sara CheleschiAntonella Fioravanti

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