The contribution of inner and outer retinal photoreceptors to infra-slow oscillations in the rat olivary pretectal nucleus

The European Journal of Neuroscience
Patrycja Orlowska-FeuerMarian H Lewandowski

Abstract

A subpopulation of olivary pretectal nucleus (OPN) neurons discharges action potentials in an oscillatory manner, with a period of approximately two minutes. This 'infra-slow' oscillatory activity depends on synaptic excitation originating in the retina. Signals from rod-cone photoreceptors reach the OPN via the axons of either classic retinal ganglion cells or intrinsically photosensitive retinal ganglion cells (ipRGCs), which use melanopsin for photon capturing. Although both cell types convey light information, their physiological functions differ considerably. The aim of the present study was to disentangle how rod-cone and melanopsin photoresponses contribute to generation of oscillatory activity. Pharmacological manipulations of specific phototransduction cascades were used whilst recording extracellular single-unit activity in the OPN of anaesthetized rats. The results show that under photopic conditions (bright light), ipRGCs play a major role in driving infra-slow oscillations, as blocking melanopsin phototransmission abolishes or transiently disturbs oscillatory firing of the OPN neurons. On the other hand, blocking rod-cone phototransmission does not change firing patterns in photopic conditions. However, under mesop...Continue Reading

References

Jul 1, 1991·The Journal of General Physiology·T TamuraK W Yau
Oct 15, 1990·The Biochemical Journal·J E MerrittT J Rink
Sep 1, 1966·Journal of Neurophysiology·R W Rodieck, P S Smith
Feb 21, 1998·Proceedings of the National Academy of Sciences of the United States of America·I ProvencioM D Rollag
Oct 26, 1999·Progress in Retinal and Eye Research·W B Thoreson, P Witkovsky
Feb 16, 2000·Neuroreport·M H LewandowskiA Wołkowska
Feb 9, 2002·Science·David M BersonMotoharu Takao
Jun 28, 2003·Science·Satchidananda PandaJohn B Hogenesch
Aug 1, 1956·Journal of the Optical Society of America·H B BARLOW
Apr 1, 1964·The Journal of Physiology·W R LEVICK, W O WILLIAMS
Dec 19, 2003·Chronobiology International·N Mrosovsky, S Hattar
Jun 15, 2004·The Journal of Biological Chemistry·Hong-Zhen HuMichael X Zhu
Sep 4, 2004·Journal of Neuroendocrinology·C H Brown
Nov 13, 2004·Vision Research·Samuel M WuJi-Jie Pang
Feb 21, 2006·Current Biology : CB·Alun R BarnardRobert J Lucas
Jun 1, 2006·The Journal of Comparative Neurology·Samer HattarDavid M Berson
Aug 26, 2006·The European Journal of Neuroscience·Jorge Alberto Perez-LeonR Lane Brown
Sep 21, 2006·The Journal of Pharmacology and Experimental Therapeutics·Donglin BaiDavid C Spray
Dec 13, 2006·The European Journal of Neuroscience·T BlasiakM H Lewandowski
Feb 27, 2007·Vision Research·Paul D R GamlinDennis M Dacey
Apr 13, 2007·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Sumathi SekaranMark W Hankins
May 19, 2007·The Journal of Physiology·Kwoon Y WongDavid M Berson
Jun 1, 2007·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·David J Margolis, Peter B Detwiler
Dec 7, 2007·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Andrew T E HartwickGary E Pickard
Feb 29, 2008·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Michael L WoodruffGordon L Fain
Dec 9, 2008·Proceedings of the National Academy of Sciences of the United States of America·C M AltimusS Hattar
Jan 2, 2009·Nature·Michael Tri H DoKing-Wai Yau

❮ Previous
Next ❯

Citations

Mar 27, 2018·The Journal of Physiology·Lukasz ChrobokMarian Henryk Lewandowski
Apr 23, 2020·Frontiers in Neuroscience·Cyril G EleftheriouRobert J Lucas
Jan 12, 2021·The Journal of Physiology·Patrycja Orlowska-FeuerRiccardo Storchi
Jan 26, 2021·Frontiers in Neuroscience·Patrycja Orlowska-FeuerMarian Henryk Lewandowski

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.