The contribution of mitochondria to sensory processing and pain

Progress in Molecular Biology and Translational Science
Sarah J L Flatters

Abstract

Mitochondria have a variety of essential functions within neurons including oxygen consumption, ATP generation, calcium buffering, and reactive oxygen species (ROS) generation. Despite extensive research into the contribution of mitochondrial function in other neurological disorders such as Parkinson's disease, the role of mitochondrial function in sensory processing and pain has been relatively unexplored until recent years. As this area of pain research is in its infancy, this review will be a descriptive summary-rather than a critical review-of data that suggests mitochondrial function/dysfunction as a causal or contributory mechanism of normal sensory processing and chronic pain. Evidence for mitochondrial dysfunction from both chronic pain patients and animal models of chronic pain will be described. Such evidence involves different aspects of mitochondria and their function including mitochondrial ultrastructure, distribution, oxygen consumption, oxidative phosphorylation, calcium buffering, ROS, and ATP levels. Most recently, substantial amounts of data have demonstrated mitochondrial involvement in painful peripheral neuropathies evoked by chemotherapy, diabetes, and HIV and these topics will be particularly highlighted...Continue Reading

Citations

Nov 26, 2016·The Journal of Pain : Official Journal of the American Pain Society·Judith A PaiceThomas J Smith
Oct 10, 2018·The Journal of Clinical Endocrinology and Metabolism·Tine Lovsø DohlmannSteen Larsen
Feb 15, 2018·PLoS Biology·Hanneke L D M WillemenNiels Eijkelkamp
Sep 7, 2018·Cellular and Molecular Neurobiology·Susana Laura GonzálezAyikoe Guy Mensah-Nyagan
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Jul 20, 2021·The Journal of Pain : Official Journal of the American Pain Society·Monika PatelKimberly T Sibille

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