The contribution of neurocognitive functions to academic and psychological outcomes in pediatric cancer: A latent profile analysis.

Child Neuropsychology : a Journal on Normal and Abnormal Development in Childhood and Adolescence
Cynthia W KarlsonRobert D Annett

Abstract

This study aimed to identify the impact of neurocognitive functioning on academic and psychological domains using a novel person-centered latent profile analysis approach. We further examined the contribution of identified risk factors (e.g., age at diagnosis, treatment) on latent class membership. 101 pediatric oncology patients and survivors (M age = 11.2, 35.6% female; 47.5% African American; M time since diagnosis = 3.4 years) completed neuropsychological evaluations at a university medical center between February 2004 and June 2017. Neurocognitive, academic, and emotional-behavioral functioning were examined using validated measures. Discreet, homogenous neurocognitive subgroups (latent classes) were identified using latent profile analysis. Demographic and medical factors were evaluated as predictors of latent class. A 3-class model indicated excellent class separation (range: .00-.04) and homogeneity (range: .94-.99). Classes were distinguished by differential cognitive patterns. Class 2 (52%) and Class 3 (25%) displayed overall normative functioning; however, Class 3 displayed significantly poorer attention than the other two classes. Class 1 (23%) demonstrated Borderline neurocognitive, low average academic, and poorer...Continue Reading

References

Apr 1, 1994·Journal of Clinical and Experimental Neuropsychology·J R Crossen, A N Wiens
Oct 8, 1999·Journal of Experimental Psychology. General·Randall W EngleAndrew R A Conway
May 22, 2003·Child Neuropsychology : a Journal on Normal and Abnormal Development in Childhood and Adolescence·Gerard A GioiaKimberly A Espy
Jul 26, 2003·Journal of Clinical Child and Adolescent Psychology : the Official Journal for the Society of Clinical Child and Adolescent Psychology, American Psychological Association, Division 53·Thomas M AchenbachLeslie A Rescorla
Aug 4, 2004·Archives of Clinical Neuropsychology : the Official Journal of the National Academy of Neuropsychologists·Susan Homack, Cynthia A Riccio
Mar 25, 2005·Journal of Pediatric Psychology·Cara B ReevesRaymond K Mulhern
Nov 25, 2005·Child Neuropsychology : a Journal on Normal and Abnormal Development in Childhood and Adolescence·Ida Sue Baron
Mar 3, 2007·Pediatrics·Joseph D Dickerman
Aug 8, 2007·Archives of Pediatrics & Adolescent Medicine·Paul C NathanUNKNOWN Children's Oncology Group Long-term Follow-up Guidelines Task Force on Neurocognitive/Behavioral Complications After Childho
Aug 21, 2007·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Kris Ann P SchultzAnn C Mertens
Jan 10, 2008·Journal of Child Neurology·Jackie L MicklewrightNicolas Krawiecki
Aug 1, 2008·Journal of Pediatric Psychology·Laura K CampbellBruce E Compas
Sep 2, 2008·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Kevin R KrullPim Brouwers
Feb 20, 2009·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·James G GurneyKirsten K Ness
Mar 4, 2009·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Lonnie K ZeltzerKevin Krull
Jul 7, 2009·Journal of Pediatric Psychology·Claire E WakefieldRichard J Cohn
Feb 22, 2011·Pediatric Blood & Cancer·Lisa S KahalleyMelissa M Hudson
Jan 25, 2012·Journal of Pediatric Psychology·Lyndsay A HarshmanNatalie L Denburg
Feb 13, 2013·Psycho-oncology·Micol E GianinazziUNKNOWN for Swiss Pediatric Oncology Group (SPOG)
Feb 4, 2014·CA: a Cancer Journal for Clinicians·Elizabeth WardAhmedin Jemal
Aug 16, 2014·Journal of Clinical and Experimental Neuropsychology·Amanda L WinterLisa S Kahalley
Jan 1, 2013·Structural Equation Modeling : a Multidisciplinary Journal·Stephanie T LanzaBethany C Bray
Apr 4, 2015·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Siobhan M PhillipsAngela B Mariotto
Jul 15, 2015·Cancer Nursing·Ida M Ki MooreMarilyn J Hockenberry

❮ Previous
Next ❯

Software Mentioned

LPA
SPSS
Mplus

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.