PMID: 11909522Mar 23, 2002Paper

The contribution of nuclear compartmentalization to gene regulation

Cell
Maria Carmo-Fonseca

Abstract

Recent developments in live-cell imaging are challenging our stereotyped view of the fixed cell nucleus. The emerging picture is that nuclear processes may rely on a constant flow of molecules between dynamic compartments created by relatively immobile binding or assembly sites. This article discusses current views on the origins of nuclear compartments and their roles in gene expression.

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