PMID: 8590145Oct 1, 1995Paper

The contribution of specific immunoglobulin M antibodies to the diagnosis of Helicobacter pylori infection in children

European Journal of Gastroenterology & Hepatology
U BleckerY Vandenplas

Abstract

To evaluate the diagnostic value of specific immunoglobulins G and M in the detection of Helicobacter pylori infection. Sera from 68 H. pylori-infected children and 35 H. pylori-negative children (aged 1-15 years) were examined using recent-generation serum enzyme-linked immunosorbent assay (ELISA) tests (Malakit Helicobacter pylori series; Biolab, Limal, Belgium). All of the investigated children had positive values for immunoglobulin G antibodies. However, anti-H. pylori-specific immunoglobulin M could be detected only in 19 (27.9%) of the 68 children. When compared with the 13C-urea breath test, these findings represent sensitivity, specificity and positive and negative predictive values of 27.9, 100, 100 and 41.7%, respectively, for the serum ELISA test for the detection of H. pylori-specific immunoglobulin M compared with 100.0, 97.2, 98.5 and 100.0%, respectively, for the Malakit for the detection of specific immunoglobulin G antibodies. Although H. pylori-specific immunoglobulin G has been established as a reliable indicator of active H. pylori infection, using the Malakit for the detection of H. pylori-specific immunoglobulin M does not seem to be of major value in the diagnosis of H. pylori infection in children.

Citations

Aug 17, 1999·Infectious Diseases in Obstetrics and Gynecology·S LanciersU Blecker
Sep 1, 1996·European Journal of Pediatrics·U Blecker
Apr 1, 1996·Clinical Pediatrics·U Blecker
Mar 16, 2018·The Cochrane Database of Systematic Reviews·Lawrence Mj BestKurinchi Selvan Gurusamy
Nov 4, 2008·Journal of Pediatric Gastroenterology and Nutrition·Carolina A SerranoPaul R Harris
Jun 10, 2000·Helicobacter·J P Gisbert, J M Pajares
May 24, 2000·Journal of Clinical Pathology·L D BallamD G Cook
Nov 26, 1999·Alimentary Pharmacology & Therapeutics·D J KearneyJ S Peacock

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