PMID: 8603035Jan 1, 1996Paper

The control and biological importance of intratumoural aromatase in breast cancer

The Journal of Steroid Biochemistry and Molecular Biology
M DowsettR Grimshaw

Abstract

The existence of aromatase activity in human breast carcinomas has been established for about 20 years but the clinical and biological importance of this remains unclear. A number of studies in clinical material suggest that aromatase activity may be a prerequisite of response to aromatase inhibitors and that aromatase activity may be enhanced in those tumours relapsing during treatment with one such inhibitor, aminoglutethimide. These results would carry more significance, however, if it was demonstrable that the growth of breast carcinomas is affected by the conversion of androgens to oestrogens by intratumoural aromatase. We have tried to address this by establishing model systems with aromatase-transfected MCF7 breast cancer cells. We have demonstrated that these cells can be stimulated mitogenically with androgen and that this proliferation is suppressible with aromatase inhibitors. Similarly the growth of aromatase transfected cells but not wild type cells as xenografts is supported by androstenedione and inhibitable by both the steroidal aromatase inhibitor, 4-hydroxyandrostenedione and non-steroidal inhibitor, CGS 20267. Work with the former of these, which is a suicide inhibitor allowed us to demonstrate that growth ca...Continue Reading

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Citations

Aug 28, 2001·Steroids·J Le BailG Habrioux
Oct 21, 1999·The Journal of Steroid Biochemistry and Molecular Biology·A D ShillingD E Williams
Aug 3, 2002·Environmental Health Perspectives·Kristian AlmstrupHenrik Leffers
Dec 10, 2003·Seminars in Oncology·Bhuvaneswari Ramaswamy, Charles L Shapiro
Oct 9, 2007·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Young H JuWilliam G Helferich
Jul 13, 2002·Expert Review of Anticancer Therapy·Paul E Goss, Robert E Smith
Apr 10, 1997·International Journal of Cancer. Journal International Du Cancer·C Moog-LutzM C Rio
Feb 5, 2008·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Ramon ColomerEmilio Alba
Jun 22, 2002·Annals of Oncology : Official Journal of the European Society for Medical Oncology·G DaviesM Dowsett

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